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Essential flexibility in the T-cell recognition of antigen

Nature volume 380, pages 495–498 (1996)Cite this article

αβ T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.

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Authors and Affiliations

  1. Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA

    Gilbert J. Kersh & Paul M. Allen

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  1. Gilbert J. Kersh
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  2. Paul M. Allen
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Kersh, G., Allen, P. Essential flexibility in the T-cell recognition of antigen. Nature 380, 495–498 (1996). https://doi.org/10.1038/380495a0

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