Inhibition of monoamine oxidase B in the brains of smokers

Abstract

THE massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking1. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders2 and is associated with a decreased risk of Parkinson's disease3. Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine4, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species5. We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.

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References

  1. 1

    Henningfield, J. E., Schuh, L. M. & Jarvik, M. E. in Psychopharmacology, the Fourth Generation of Progress (eds Bloom, F. W. & Kupfer, D. J.) Ch. 147, 1715–1729 (Raven, New York 1995).

    Google Scholar 

  2. 2

    Hughes, J. R., Hatsukama, D. K., Mitchell, J. E. & Dahlgren, L. A. Am. J. Psychiatry 143, 993–997 (1986).

    CAS  Article  Google Scholar 

  3. 3

    Morens, D. M., Grandinetti, A., Reed, D., White, L. R. & Ross, G. W. Neurology 45, 1041–1051 (1995).

    CAS  Article  Google Scholar 

  4. 4

    Berry, M. D., Juorio, A. V. & Paterson, I. A. Prog. Neurobiol. 42, 375–391 (1994).

    CAS  Article  Google Scholar 

  5. 5

    Reiter, R. J. FASEB J. 9, 526–533 (1995).

    CAS  Article  Google Scholar 

  6. 6

    Fowler, J. S. et al. J. Neurochem. 51, 1524–1534 (1988).

    CAS  Article  Google Scholar 

  7. 7

    Fowler, J. S. et al. J. nucl. Med. 36, 1255–1262 (1995).

    CAS  PubMed  Google Scholar 

  8. 8

    Patlak, C. S., Blasberg, R. G. & Fenstermacher, J. D. J. cereb. Blood Flow Metab. 3, 1–7 (1983).

    CAS  Article  Google Scholar 

  9. 9

    Yamashita, K., Kobayashi, S., Yamaguchi, S., Kitani, M. & Tsunematsu, T. Gerontology 34, 199–204 (1988).

    CAS  Article  Google Scholar 

  10. 10

    Wang, G.-J., Volkow, N. D., Wolf, A. P., Brodie, J. D. & Hitzemann, R. J. J. nucl. Med. 35, 1457–1466 (1994).

    CAS  PubMed  Google Scholar 

  11. 11

    Stapleton, J. M. et al. National Institute on Drug Abuse Res Monogr. Ser. Vol. 132, 106 (Department of Health and Human Services, Washington DC, 1993).

    Google Scholar 

  12. 12

    Riederer, P. & Youdim, M. B. H. J. Neurochem. 46, 1359–1365 (1986).

    CAS  Article  Google Scholar 

  13. 13

    Oreland., L., Fowler, C. J. & Schalling, D. Life Sci. 29, 2511–2518 (1981).

    CAS  Article  Google Scholar 

  14. 14

    Norman, T. R., Chamberlain, K. G. & French, M. A. Psychiatry Res. 20, 199–205 (1987).

    CAS  Article  Google Scholar 

  15. 15

    Carr, L. A. & Rowell, P. P. Neuropharmacology 29, 311–314 (1990).

    CAS  Article  Google Scholar 

  16. 16

    Pavlin, R. & Sket, D. Farmacentski Vest. 44, 185–192 (1993).

    CAS  Google Scholar 

  17. 17

    Yu, P. H. & Boulton, A. A. Life Sci. 41, 675–682 (1987).

    CAS  Article  Google Scholar 

  18. 18

    Carr, L. A. & Basham, J. K. Life Sci. 48, 1173–1177 (1991).

    CAS  Article  Google Scholar 

  19. 19

    Fowler, J. S. et al. Synapse 18, 86–93 (1994).

    CAS  Article  Google Scholar 

  20. 20

    Boulton, A. A., Yu, P. H. & Tipton, K. F. Lancet i 114–115 (1988).

    Article  Google Scholar 

  21. 21

    Yong, V. W. & Perry, T. L. J. neurol. Sci. 72, 265–272 (1986).

    CAS  Article  Google Scholar 

  22. 22

    Tetrud, J. W. & Langston, J. W. Science 245, 519–522 (1989).

    ADS  CAS  Article  Google Scholar 

  23. 23

    Tariot, P. N., Cohen, R. M., Sunderland, T., Weingartner, H. & Murphey, D, L. Psychopharmacology 91, 489–495 (1987).

    CAS  Article  Google Scholar 

  24. 24

    Knoll, J., Yen, T. T. & Miklya, I. Life Sci. 54, 1047–1057 (1994).

    CAS  Article  Google Scholar 

  25. 25

    Dluzen. D. E. & McDermott, J. L. J. neural Trans. 85, 145–156 (1991).

    CAS  Article  Google Scholar 

  26. 26

    Jackson, D. M. & Westlind-Danielsson, A. in Pharmacology and Therapeutics Vol. 64 (ed. Mitchelson, F.) 291–369 (Pergamon, UK, 1994).

    Google Scholar 

  27. 27

    Di Chiara, G. & Imperato, A. Proc. natn. Acad. Sci. U.S.A. 85, 5274–5278 (1988).

    ADS  CAS  Article  Google Scholar 

  28. 28

    Paterson, I. A., Juorio, A. V., Berry, M. D. & Zhu, M. Y. J. Pharmacol. exp. Ther. 258, 1019–1026 (1991).

    CAS  PubMed  Google Scholar 

  29. 29

    Jossan, S. S., Sakurai, E. & Oreland, L. Biogenic Amines 4, 371–379 (1987).

    CAS  Google Scholar 

  30. 30

    Dougherty. E. An Introduction to Morphological Image Processing (SPIE Optical Engineering Press, Bellingham, WA, 1992).

    Google Scholar 

  31. 31

    Berlin, I. et al. Clin. Pharmac. Ther. 58, 444–452 (1995).

    CAS  Article  Google Scholar 

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Correspondence to J. S. Fowler.

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Fowler, J., Volkow, N., Wang, G. et al. Inhibition of monoamine oxidase B in the brains of smokers. Nature 379, 733–736 (1996). https://doi.org/10.1038/379733a0

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