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Apoptosis of T cells mediated by galectin-1

Nature volume 378, pages 736–739 (1995)Cite this article

Abstract

GALECTIN-1, a member of the family of β-galactoside binding proteins1, has growth regulatory and immunomodulatory activities2–4. We report here that galectin-1, expressed by stromal cells in human thymus and lymph nodes5,6, is present at sites of cell death by apoptosis during normal T-cell development and maturation. Galectin-1 induced apoptosis of activated human T cells and human T leukaemia cell lines. Resting T cells also bound galectin-1, but did not undergo apoptosis. Human endothelial cells that expressed galectin-1 induced apoptosis of bound T cells. Galectin-1-induced apoptosis required expression of CD45, and was decreased when N-glycan elongation was blocked by treatment of the cells by swainsonine7, whereas inhibition of O-glycan elongation8 potentiated the apoptotic effect of galectin-1. Induction of apoptosis by an endogenous mammalian lectin represents a new mechanism for regulating the immune response.

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References

  1. Barondes, S. H. et al. Cell 76, 597–598 (1994).

    CAS  Article  Google Scholar 

  2. Wells, V. & Mallucci, L. Cell 64, 91–97 (1991).

    CAS  Article  Google Scholar 

  3. Levi, G., Tarrab-Hazdai, R. & Teichberg, V. I. Eur. J. Immun. 13, 500–507 (1983).

    CAS  Article  Google Scholar 

  4. Offner, H. et al. J. Neuroimmun. 28, 177–184 (1990).

    CAS  Article  Google Scholar 

  5. Baum, L. G., Pang, M., Perillo, N. L., Wu, T. & Seilhamer, J. J. J. exp. Med. 181, 877–887 (1995).

    CAS  Article  Google Scholar 

  6. Baum, L. G. et al. Glycoconjugate J. 12, 63–68 (1995).

    CAS  Article  Google Scholar 

  7. Elbein, A. D. A. Rev. Biochem. 56, 497–534 (1987).

    CAS  Article  Google Scholar 

  8. Kuan, S.-F., Byrd, J. C., Basbaum, C. & Kim, Y. S. J. biol. Chem. 264, 19271–19277 (1989).

    CAS  PubMed  Google Scholar 

  9. Hirabayashi, J. & Kasai, K.-i. Glycobiology 3, 297–304 (1993).

    CAS  Article  Google Scholar 

  10. Barondes, S. H., Cooper, D. N. W., Gitt, M. A. & Leffler, H. J. biol. Chem. 269, 20807–20810 (1994).

    CAS  PubMed  Google Scholar 

  11. Hughes, R. C. Curr. Opin. struct. Biol. 2, 687–692 (1992).

    MathSciNet  CAS  Article  Google Scholar 

  12. Liao, D-I., Kapadia, G., Ahmed, H., Vasta, G. R. & Herzberg, O. Proc. natn. Acad. Sci. U.S.A. 91, 1428–1432 (1994).

    ADS  CAS  Article  Google Scholar 

  13. Bourne, Y. et al. Nature struct. Biol. 1, 863–870 (1994).

    CAS  Article  Google Scholar 

  14. Cooper, D. N. W., Massa, S. M. & Barondes, S. H. J. Cell Biol. 115, 1437–1448 (1991).

    CAS  Article  Google Scholar 

  15. Allen, H. J. et al. J. Cell Biochem. 43, 43–57 (1990).

    CAS  Article  Google Scholar 

  16. Zhou, Q. & Cummings, R. D. Arch. Biochem. Biophys. 300, 6–17 (1993).

    CAS  Article  Google Scholar 

  17. Lee, R. T., Ishikawa, Y., Allen, H. J. & Lee, Y. C. J. biol. Chem. 265, 7864–7871 (1990).

    CAS  PubMed  Google Scholar 

  18. Duvall, E. & Wyllie, A. H. Immun. Today 7, 115–119 (1986).

    CAS  Article  Google Scholar 

  19. Telford, W. G., King, L. E. & Fraker, P. J. Cytometry 13, 137–143 (1992).

    CAS  Article  Google Scholar 

  20. Cho, M. & Cummings, R. D. J. biol. Chem 270, 5207–5212 (1995).

    CAS  Article  Google Scholar 

  21. Harrison, F. L. & Chesterton, C. J. FEBS Lett. 122, 157–165 (1980).

    CAS  Article  Google Scholar 

  22. Wesselborg, S., Janssen, O. & Kabelitz, D. J. Immun. 150, 4338–4345 (1993).

    CAS  PubMed  Google Scholar 

  23. Goldstone, S. D. & Lavin, M. F. Biochem. biophys. Res. Commun. 178, 746–750 (1991).

    CAS  Article  Google Scholar 

  24. Su, X. et al. Immunity 2, 353–362 (1995).

    CAS  Article  Google Scholar 

  25. Trauth, B. C. et al. Science 245, 150–157 (1994).

    Google Scholar 

  26. Ong, C. J., Chui, D., Teh, H.-S. & Marth, J. D. J. Immun. 152, 3793–3805 (1994).

    CAS  PubMed  Google Scholar 

  27. Koretzky, G. A., Picus, J., Thomas, M. L. & Weiss, A. Nature 346, 66–68 (1990).

    ADS  CAS  Article  Google Scholar 

  28. Pulido, R. & Sanchez-Madrid, F. Eur. J. Immun. 20, 2667–2671 (1990).

    CAS  Article  Google Scholar 

  29. Bezouska, K. et al. Nature 372, 150–157 (1994).

    ADS  CAS  Article  Google Scholar 

  30. Gavrieli, Y., Sherman, Y. & Ben-Sasson, S. A. J. Cell Biol. 119, 493–501 (1992).

    CAS  Article  Google Scholar 

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Author notes

  1. Jeffrey J. Seilhamer: Incyte Pharmaceuticals Inc., 3174 Porter Drive, Palo Alto, California 94304, USA

  2. Linda G. Baum: To whom correspondence should be addressed.

Affiliations

  1. UCLA Department of Pathology and Laboratory Medicine, 10833 Le Conte Avenue, Los Angeles, California, 90095-1732, USA

    Nancy L. Perillo, Karen E. Pace, Jeffrey J. Seilhamer & Linda G. Baum

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  1. Nancy L. Perillo
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  2. Karen E. Pace
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  3. Jeffrey J. Seilhamer
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  4. Linda G. Baum
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Perillo, N., Pace, K., Seilhamer, J. et al. Apoptosis of T cells mediated by galectin-1. Nature 378, 736–739 (1995). https://doi.org/10.1038/378736a0

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