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A homeobox gene essential for zebrafish notochord development

Nature volume 378, pages 150157 (09 November 1995) | Download Citation

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Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

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Author information

Affiliations

  1. Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA

    • William S. Talbot
    • , Marnie E. Halpern
    • , Anna E. Melby
    • , John H. Postlethwait
    •  & Charles B. Kimmel
  2. Department of Biochemistry and Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK

    • Bill Trevarrow
    •  & Trevor Jowett
  3. Department of Biochemistry, Box 357350, University of Washington, Seattle, Washington 98195-7350, USA

    • Gist Farr
    •  & David Kimelman
  4. Present addresses: Division of Biology 139-74, Caltech, Pasadena, California, 91125, USA (B.T.); Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, Maryland 21210, USA (M.E.H.).

    • Bill Trevarrow
    •  & Marnie E. Halpern
  5. To whom correspondence should be addressed.

    • David Kimelman

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https://doi.org/10.1038/378150a0

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