Article | Published:

A homeobox gene essential for zebrafish notochord development

Naturevolume 378pages150157 (1995) | Download Citation

Subjects

Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Spemann, H. & Mangold, H. Wilhelm Roux Arch. EntwMech. Org. 100, 599–638 (1924).

  2. 2

    Keller, R. E. Devl Biol. 51, 118–137 (1976).

  3. 3

    Kimmel, C. B., Warga, R. M. & Schilling, T. F. Development 108, 581–594 (1990).

  4. 4

    Ruiz i Altaba, A. Development 115, 67–80 (1992).

  5. 5

    Placzek, M., Tessier-Levigne, M., Yamada, T., Jessell, T. M. & Dodd, J. Science 250, 985–988 (1990).

  6. 6

    van Straaten, H. W. M., Hekking, J. W. M., Wiertz-Hoessels, E. L., Thors, F. & Drukker, J. Anat. Embryol. 177, 317–324 (1988).

  7. 7

    Fan, C.-M. & Tessier-Levigne, M. Cell 79, 1175–1186 (1994).

  8. 8

    Halpern, M. E., Ho, R. K., Walker, C. & Kimmel, C. B. Cell 75, 99–111 (1993).

  9. 9

    Cho, K. W. Y., Blumberg, B., Steinbeisser, H. & De Robertis, E. M. Cell 67, 1111–1120 (1991).

  10. 10

    Ruiz i Altaba, A. & Jessel, T. M. Development 116, 81–93 (1992).

  11. 11

    Dirksen, M. L. & Jamrich, M. Genes Dev. 6, 599–608 (1992).

  12. 12

    Ang, S.-L. et al. Development 119, 1301–1315 (1993).

  13. 13

    Sasaki, H. & Hogan, B. L. M. Development 118, 47–59 (1993).

  14. 14

    Taira, M., Jamrich, M., Good, P. J. & Dawid, I. B. Genes Dev. 6, 356–366 (1992).

  15. 15

    Herrmann, B. G., Labeit, S., Poustka, A., King, T. R. & Lehrach, H. Nature 343, 617–622 (1990).

  16. 16

    Wilkinson, D. G., Bhatt, S. & Herrmann, B. G. Nature 343, 657–659 (1990).

  17. 17

    Schulte-Merker, S., Ho, R. K., Herrmann, B. G. & Nüsslein-Volhard, C. Development 116, 1021–1032 (1992).

  18. 18

    von Dassow, G., Schmidt, J. E. & Kimelman, D. Genes Dev. 7, 355–366 (1993).

  19. 19

    Gont, L. K., Steinbeisser, H., Blumberg, B. & DeRobertis, E. M. Development 119, 991–1004 (1993).

  20. 20

    Ang, S.-L. & Rossant, J. Cell 78, 561–574 (1994).

  21. 21

    Weinstein, D. C. et al. Cell 78, 575–588 (1994).

  22. 22

    Stachel, S. E., Grunwald, D. J. & Myers, P. Z. Development 117, 1261–1274 (1993).

  23. 23

    Schulte-Merker, S., Van Eeden, F. J. M., Halpern, M. E., Kimmel, C. B. & Nüsslein-Volhard, C. Development 120, 1009–1015 (1994).

  24. 24

    Chesley, P. J. exp. Zool. 70, 429–435 (1935).

  25. 25

    Hatta, K., Kimmel, C. B., Ho, R. K. & Walker, C. Nature 350, 339–341 (1991).

  26. 26

    Solnica-Krezel, L., Schier, A. F. & Driever, W. Genetics 136, 1401–1420 (1994).

  27. 27

    Mullins, M. C., Hammerschmidt, M., Haffter, P. & Nüsslein-Volhard, C. Curr. Biol. 4, 189–202 (1994).

  28. 28

    Henion, P. D. et al. Devl Genet. (in the press).

  29. 29

    Hatta, K. Neuron 9, 629–642 (1992).

  30. 30

    Smith, J. C. & Watt, F. M. Differentiation 29, 109–115 (1985).

  31. 31

    Yamada, T., Pfaff, S., Edlund, T. & Jessell, T. M. Cell 73, 673–686 (1993).

  32. 32

    Echelard, Y. et al. Cell 75, 1417–1430 (1993).

  33. 33

    Roelink, H. et al. Cell 76, 761–775 (1994).

  34. 34

    Krauss, S., Concordet, J.-P. & Ingham, P. W. Cell 75, 1431 (1993).

  35. 35

    Dessain, S. & McGinnis, W. Adv. dev. Biol. 2, 1–54 (1993).

  36. 36

    Helde, K. A. & Grunwald, D. J. Devl Biol. 159, 418–426 (1993).

  37. 37

    Stein, S. & Kessel, M. Mech. Dev. 49, 37–48 (1995).

  38. 38

    Dalton, D., Chadwick, R. & McGinnis, W. Genes Dev. 3, 1940–1956 (1989).

  39. 39

    Simeone, A. et al. EMBO J. 11, 2541–2550 (1992).

  40. 40

    Postlethwait, J. E. et al. Science 264, 699–703 (1994).

  41. 41

    Williams, J. G. K., Kubelik, A. R., Livak, K. J., Rafalski, J. A. & Tingey, S. V. Nucleic Acids Res. 18, 6531–6536 (1990).

  42. 42

    Oppenheimer, J. M. J. exp. Zool. 140, 247–268 (1959).

  43. 43

    Ho, R. K. Semin dev. Biol. 3, 53–64 (1992).

  44. 44

    Halpern, M. E. et al. Development 121, 4257–4264 (1995).

  45. 45

    Yan, Y.-L., Hatta, K., Riggleman, B. & Postlethwait, J. H. Devl Dyn. 203, 363–376 (1995).

  46. 46

    Thisse, C., Thisse, B., Schilling, T. F. & Postlethwait, J. H. Development 119, 1203–1215 (1993).

  47. 47

    Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. & Schilling, T. F. Devl Dyn. 203, 253–310 (1995).

  48. 48

    Trevarrow, B., Marks, D. & Kimmel, C. B. Neuron 4, 669–679 (1990).

  49. 49

    Pike, S. H., Melancon, E. F. & Eisen, J. S. Development 144, 825–831 (1992).

  50. 50

    Eisen, J. S., Pike, S. H. & Debu, B. Neuron 2, 1097–1104 (1989).

  51. 51

    Michelmore, R. W., Paran, I. & Kesseli, R. V. Proc. natn. Acad. Sci. U.S.A. 88, 9828–9832 (1991).

Download references

Author information

Author notes

    • Bill Trevarrow

    Present address: Division of Biology 139-74, Caltech, Pasadena, California, 91125, USA

    • Marnie E. Halpern

    Present address: Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland, 21210, USA

  1. David Kimelman: To whom correspondence should be addressed.

Affiliations

  1. Institute of Neuroscience, University of Oregon, Eugene, Oregon, 97403, USA

    • William S. Talbot
    • , Marnie E. Halpern
    • , Anna E. Melby
    • , John H. Postlethwait
    •  & Charles B. Kimmel
  2. Department of Biochemistry and Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK

    • Bill Trevarrow
    •  & Trevor Jowett
  3. Department of Biochemistry, University of Washington, Box 357350, Seattle, Washington, 98195-7350, USA

    • Gist Farr
    •  & David Kimelman

Authors

  1. Search for William S. Talbot in:

  2. Search for Bill Trevarrow in:

  3. Search for Marnie E. Halpern in:

  4. Search for Anna E. Melby in:

  5. Search for Gist Farr in:

  6. Search for John H. Postlethwait in:

  7. Search for Trevor Jowett in:

  8. Search for Charles B. Kimmel in:

  9. Search for David Kimelman in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/378150a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.