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A sex difference in the human brain and its relation to transsexuality


TRANSSEXUALS have the strong feeling, often from childhood onwards, of having been born the wrong sex. The possible psycho-genie or biological aetiology of transsexuality has been the subject of debate for many years1,2. Here we show that the volume of the central subdivision of the bed nucleus of the stria terminalis (BSTc), a brain area that is essential for sexual behaviour3,4, is larger in men than in women. A female-sized BSTc was found in male-to-female transsexuals. The size of the BSTc was not influenced by sex hormones in adulthood and was independent of sexual orientation. Our study is the first to show a female brain structure in genetically male transsexuals and supports the hypothesis that gender identity develops as a result of an interaction between the developing brain and sex hormones5,6.

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  1. Money, J. & Gaskin, R. J. Int. J. Psychiatry 9, 249 (1970/71).

    PubMed  Google Scholar 

  2. Gooren, L. J. G. Psychoneuroendocrinology 15, 3–14 (1990).

    Article  CAS  Google Scholar 

  3. Kawakami, M. & Kimura, F. Endocrinol. Jap. 21, 125–130 (1974).

    Article  CAS  Google Scholar 

  4. Emery, D. E. & Sachs, B. D. Physiol. Behav. 17, 803–806 (1976).

    Article  CAS  Google Scholar 

  5. Editorials Lancet 338, 603–604 (1991).

  6. Swaab, D. F. & Hofman, M. A. Trends Neurosci. 18, 264–270 (1995).

    Article  CAS  Google Scholar 

  7. Money, J., Schwartz, M. & Lewis, V. G. Psychoneuroendocrinology 9, 405–414 (1984).

    Article  CAS  Google Scholar 

  8. Sheridan, P. J. Endocrinology 104, 130–136 (1979).

    Article  CAS  Google Scholar 

  9. Commins, D. & Yahr, D. J. comp. Neurol. 231, 473–489 (1985).

    Article  CAS  Google Scholar 

  10. Jakab, R. L., Horvath, T. L., Leranth, C., Harada, N. & Naftolin, F. J. Steroid Biochem. molec. Biol. 44, 481–498 (1993).

    Article  CAS  Google Scholar 

  11. Eiden, E. L., Hökfelt, T., Brownstein, M. J. & Palkovits, M. Neuroscience 15, 999–1013 (1985).

    Article  CAS  Google Scholar 

  12. De Olmos, J. S. in The Human Nervous System (ed. Paxinos, G.) 597–710 (Academic, San Diego, 1990).

    Google Scholar 

  13. Woodhams, P. L., Roberts, G. W., Polak, J. M. & Crow, T. J. Neuroscience 8, 677–703 (1983).

    Article  CAS  Google Scholar 

  14. Simerly, R. B. Trends Neurosci. 13, 104–110 (1990).

    Article  CAS  Google Scholar 

  15. Arluison, M. et al. Brain Res. Bull. 34, 319–337 (1994).

    Article  CAS  Google Scholar 

  16. Bleier, R., Byne, W. & Siggelkow, I. J. comp. Neurol. 212, 118–130 (1982).

    Article  CAS  Google Scholar 

  17. Del Abril, A., Segovia, S. & Guillamón, A. Devl Brain Res. 32, 295–300 (1987).

    Article  Google Scholar 

  18. Guillamón, A., Segovia, S. & Del Abril, A. Devl Brain Res. 44, 281–290 (1988).

    Article  Google Scholar 

  19. Allen, L. A. & Gorski, R. A. J. comp. Neurol. 302, 697–706 (1990).

    Article  CAS  Google Scholar 

  20. Walter, A., Mai, J. K., Lanta, L. & Görcs, T. J. Chem. Neuroanat. 4, 281–298 (1991).

    Article  CAS  Google Scholar 

  21. Claro, F., Segovia, S., Guilamón, A. & Del Abril, A. Brain Res. Bull. 36, 1–10 (1995).

    Article  CAS  Google Scholar 

  22. Simerly, R. B. & Swanson, L. W. Proc. natn. Acad. Sci. U.S.A. 84, 2087–2091 (1987).

    Article  ADS  CAS  Google Scholar 

  23. De Vries, G. J. N. Neuroendocr. 20, 1–13 (1990).

    Google Scholar 

  24. Pilgrim, C. & Reisert, I. Horm. metab. Res. 24, 353–359 (1992).

    Article  CAS  Google Scholar 

  25. Swaab, D. F., Zhou, J. N., Ehlhart, T. & Hofman, M. A. Brain. Res. 79, 249–259 (1994).

    Article  CAS  Google Scholar 

  26. Zhou, J. N., Hofman, M. A. & Swaab, D. F. Neurobiol. Aging 16, 571–576 (1995).

    Article  CAS  Google Scholar 

  27. Zhou, J. N., Hofman, M. A. & Swaab, D. F. Brain Res. 672, 285–288 (1995).

    Article  CAS  Google Scholar 

  28. Swaab D. F. & Hofman, M. A. Brain Res. 537, 141–148 (1990).

    Article  CAS  Google Scholar 

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Zhou, JN., Hofman, M., Gooren, L. et al. A sex difference in the human brain and its relation to transsexuality. Nature 378, 68–70 (1995).

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