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Transcription complex stability and chromatin dynamics in vivo

Nature volume 377, pages 209–213 (1995)Cite this article

Abstract

Distant regulatory sequences affect transcription through long-range chromatin interactions. Visualization of transcriptional activity of genes that compete for distant elements, using the globin locus as a model, has revealed the dynamics of chromatin interactions in vivo. Multiple genes appear to be transcribed alternately rather than at the same time to generate several messenger RNAs in one cell. The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism.

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Authors and Affiliations

  1. MGC Department of Cell Biology and Genetics, Erasmus University, 3015 GE, Rotterdam, The Netherlands

    Mark Wijgerde, Frank Grosveld & Peter Fraser

  2. Laboratory of Gene Structure and Expression, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Frank Grosveld

Authors
  1. Mark Wijgerde
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  2. Frank Grosveld
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  3. Peter Fraser
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Wijgerde, M., Grosveld, F. & Fraser, P. Transcription complex stability and chromatin dynamics in vivo. Nature 377, 209–213 (1995). https://doi.org/10.1038/377209a0

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