DURING 1977-91, 6,278 males diagnosed with haemophilia were living in the UK. During 1979-86, 1,227 were infected with the human immunodeficiency virus (HIV-1) as a result of transfusion therapy (median estimated seroconversion date, October 1982). Among 2,448 with severe haemophilia, the annual death rate was stable at 8 per 1,000 during 1977-84; during 1985-92 death rates remained at 8 per 1,000 among HIV-seronegative patients but rose steeply in seropositive patients, reaching 81 per 1,000 in 1991-92. Among 3,830 with mild or moderate haemophilia, the pattern was similar, with an initial death rate of 4 per 1,000 in 1977-84, rising to 85 per 1,000 in 1991-92 in seropositive patients. During 1985-92, there were 403 deaths in HIV seropositive patients, whereas 60 would have been predicted from rates in seronegatives, suggesting that 85% of the deaths in seropositive patients were due to HIV infection. Most of the excess deaths were certified as due to AIDS or to conditions recognized as being associated with AIDS.
This is a preview of subscription content
Subscribe to Journal
Get full journal access for 1 year
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Get time limited or full article access on ReadCube.
All prices are NET prices.
Rizza, C. R. & Spooner, R. J. D. Br. med. J. 286, 929–933 (1983).
Cheingsong-Popov, R. et al. Br. med. J. 293, 168–169 (1986).
AIDS Group of the UK Haemophilia Centre Directors. Phil. Trans. R. Soc. Lond. B 325, 179–183 (1989).
Darby, S. C. et al. Br. med. J. 298, 1064–1068 (1989).
Darby, S. C., Doll, R., Thakrar, B., Rissa, C. R. & Cox, D. R. Stat. Med. 9, 681–689 (1990).
US Department of Health and Human Services Morbidity and Mortality Weekly Report 38, S-5, 1–9 (1989).
Concorde Coordinating Committee Lancet 343, 871–881 (1994).
Goedert, J. J. et al. Lancet 344, 791–792 (1994).
Johnson, R. E. et al. Am. J. Epidemiol. 121, 797–810 (1985).
Aronson, D. L. Am. J. Hemat. 27, 7–12 (1988).
Rosendaal, F. R. et al. Brit. J. Haemat. 71, 71–76 (1989).
Koumbarelis, E. et al. Thromb. Haemost. 72, 808–813 (1994).
Chorba, T. L., Holman, R. C., Strine, T. W., Clarke, M. J. & Evatt, B. L. Am. J. Hemat. 45, 112–121 (1994).
Telfer, P. et al. Br. J. Haemat. 87, 555–561 (1994).
Colombo, M. et al. Am. J. Hemat. 37, 243–246 (1991).
Cuthbert, R. J. G. et al. Br. med. J. 301, 956–961 (1990).
Jones, P. et al. Br. med. J. 291, 695–699 (1985).
Lee, C. A. et al. Br. med. J. 303, 1093–1096 (1991).
Aronstam, A. et al. Arch. Dis. Child, 68, 521–524 (1993).
World Health Organization Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death (WHO, Geneva, 1977).
McCormick, A. Population Trends 76, 1–7 (1994).
Fischl, M. A. et al. N. Engl. J. Med. 317, 185–191 (1987).
Williams, M. D., Al-Rubei, K. & Hill, F. G. H. Thromb. Haemost. 60, 97–101 (1988).
Smith, G. M. et al. Clin. Lab. Haemat. 13, 115–125 (1991).
About this article
Cite this article
Darby, S., Ewart, D., Giangrande, P. et al. Mortality before and after HIV infection in the complete UK population of haemophiliacs. Nature 377, 79–82 (1995). https://doi.org/10.1038/377079a0
AIDS and Behavior (2010)
Nature Immunology (2007)
Nature Medicine (2004)
The Indian Journal of Pediatrics (2003)
The chemical bases of the various AIDS epidemics: Recreational drugs, anti-viral chemotherapy and malnutrition
Journal of Biosciences (2003)