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Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells

Nature volume 376, pages 355–358 (1995)Cite this article

Abstract

AN important feature of natural killer (NK) cell activity is the lysis of cells that have extinguished expression of some or all class I major histocompatibility (MHC) molecules1-7. Accordingly, the Ly49A NK-cell antigen receptor has been shown to deliver an inhibitory signal to NK cells on encounter with Dd or Dk class I MHC on target cells4. Ly49A belongs to a family of eight or more highly related, tightly linked genes2,8-10. Expression of Ly49A and Ly49C, another member of the Ly49 family with distinct MHC specificity, define subpopulations of NK cells that are only partly overlapping10-12. The mechanisms regulating the expression of Ly49 family members are unknown. We show here that the Ly49A and Ly49C NK-cell receptors are each subject to allelic exclusion. Because Ly49 genes are not thought to undergo DNA rearrangement13,14, allelic exclusion of Ly49 genes could involve a mechanism distinct from that used by B and T lymphocytes15,16 and is likely to play an important role in the genesis of a putative NK-cell repertoire specific for class I molecules.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California, 94720, USA

    Werner Held & David H. Raulet

  2. Département d'lmmunologie Institut Pasteur, 25 rue du Dr Roux, 75724, Paris Cedex, France

    Jacques Roland

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  1. Werner Held
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  2. Jacques Roland
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  3. David H. Raulet
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Held, W., Roland, J. & Raulet, D. Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells. Nature 376, 355–358 (1995). https://doi.org/10.1038/376355a0

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