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Protein molecules as computational elements in living cells

Nature volume 376, pages 307–312 (1995)Cite this article

An Erratum to this article was published on 01 November 1995

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Abstract

Many proteins in living cells appear to have as their primary function the transfer and processing of information, rather than the chemical transformation of metabolic intermediates or the building of cellular structures. Such proteins are functionally linked through allosteric or other mechanisms into biochemical 'circuits' that perform a variety of simple computational tasks including amplification, integration and information storage.

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References

  1. Stryer, L. Biochemistry (Freeman, San Francisco, 1995).

    Google Scholar 

  2. Johnson, L. N. & Barford, D. A. Rev. Biophys. struct. Biol. 22, 199–232 (1994).

    Article  Google Scholar 

  3. Hanson, P. I., Meyer, T., Stryer, L. & Schulman, H. Neuron 12, 943–956 (1994).

    Article  CAS  Google Scholar 

  4. Anwyl, R. Curr. Biol. 4, 854–856 (1994).

    Article  CAS  Google Scholar 

  5. Pawson, T. & Schlessinger, J. Curr. Biol. 3, 434–442 (1993).

    Article  CAS  Google Scholar 

  6. Saltiel, A. R. FASEB J. 8, 1034–1040 (1994).

    Article  CAS  Google Scholar 

  7. Morgan, D. O., Kaplan, J. M., Bishop, J. M. & Varmus, H. E. Cell 57, 775–786 (1989).

    Article  CAS  Google Scholar 

  8. Roach, P. J. FASEB J. 4, 2961–2968 (1990).

    Article  CAS  Google Scholar 

  9. Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, MA, 1992).

    Google Scholar 

  10. McCulloch, W. S. & Pitts, W. Bull. math. Biophys. 5, 115–133 (1943).

    Article  MathSciNet  Google Scholar 

  11. Minsky, M. & Papert, S. Perceptrons (MIT Press, Cambridge, MA, 1969).

    MATH  Google Scholar 

  12. Rumelhart, D. E., McClelland, J. L. Parallel Distributed Processing. Explorations in the Microstructure of Cognition (MIT Press, Boston, MA, 1986).

    Google Scholar 

  13. Arkin, A. & Ross, J. Biophys. J. 67, 560–578 (1994).

    Article  ADS  CAS  Google Scholar 

  14. Shacter, E., Chock, P. B. & Stadtman, E. R. J. biol. Chem. 259, 12252–12259 (1984).

    CAS  PubMed  Google Scholar 

  15. Stadtman, E. R. & Chock, P. B. Proc. natn. Acad. Sci. U.S.A. 74, 2761–2765 (1977).

    Article  ADS  CAS  Google Scholar 

  16. Goldbeter, A. & Koshland, D. E. Proc. natn. Acad. Sci. U.S.A. 78, 6840–6844 (1981).

    Article  ADS  CAS  Google Scholar 

  17. Bourne, H. R., Sanders, D. A. & McCormick, F. Nature 348, 125–132 (1990).

    Article  ADS  CAS  Google Scholar 

  18. Hepler, J. R. & Gilman, A. G. Trends biochem. Sci. 17, 383–387 (1992).

    Article  CAS  Google Scholar 

  19. Boguski, M. S. & McCormick, F. Nature 366, 643–654 (1993).

    Article  ADS  CAS  Google Scholar 

  20. Hall, A. Science 264, 1413–1414 (1994).

    Article  ADS  CAS  Google Scholar 

  21. Gilman, A. G. A. Rev. Biochem. 56, 615–649 (1987).

    Article  CAS  Google Scholar 

  22. Chock, P. B. & Stadtman, E. R. Proc. natn. Acad. Sci. U.S.A. 74, 2766–2770 (1977).

    Article  ADS  CAS  Google Scholar 

  23. Okamoto, M., Sakai, T. & Hayashi, K. Biol. Cybern. 58, 295–299 (1988).

    Article  CAS  Google Scholar 

  24. Hjelmfelt, A., Schneider, F. W. & Ross, J. Science 260, 335–337 (1993).

    Article  ADS  CAS  Google Scholar 

  25. Bray, D. & Lay, S. Biophys. J. 66, 972–977 (1994).

    Article  ADS  CAS  Google Scholar 

  26. Koshland, D. E., Goldbeter, A. & Stock, J. B. Science 217, 220–225 (1982).

    Article  ADS  CAS  Google Scholar 

  27. Lamb, T. D. & Pugh, E. N. J. Physiol. Lond. 449, 710–758 (1992).

    Article  Google Scholar 

  28. Stryer, L. Cold Spring Harb, Symp. quant. Biol. 53, 283–294 (1988).

    Article  CAS  Google Scholar 

  29. Bray, D., Bourret, R. B. & Simon, M. I. Molec. Biol. Cell 4, 469–482 (1993).

    Article  CAS  Google Scholar 

  30. Parkinson, J. S. & Kofoid, E. C. A. Rev. Genet. 26, 71–112 (1992).

    Article  CAS  Google Scholar 

  31. Berg, H. C. & Tedesco, P. M. Proc. natn. Acad. Sci. U.S.A. 72, 3235–3239 (1975).

    Article  ADS  CAS  Google Scholar 

  32. Lin, D. M. & Goodman, C. S. Neuron 13, 507–523 (1994).

    Article  CAS  Google Scholar 

  33. Kishimoto, T., Taga, T. & Akira, S. Cell 76, 253–262 (1994).

    Article  CAS  Google Scholar 

  34. Tjian, R. & Maniatis, T. Cell 77, 5–8 (1994).

    Article  CAS  Google Scholar 

  35. Anholt, R. R. H. Trends Neurosci. 17, 37–41 (1994).

    Article  CAS  Google Scholar 

  36. Murray, A. & Hunt, T. The Cell Cycle (Oxford Univ. Press, Oxford. 1993).

    Google Scholar 

  37. Bray, D. Cell Movements (Garland Publishing, New York, 1992).

    Google Scholar 

  38. Bray, D. J. theor. Biol. 143, 215–231 (1990).

    Article  CAS  Google Scholar 

  39. Zimmerman, S. B. & Minton, A. P. A. Rev. Biophys. struct. Biol. 22, 27–65 (1994).

    Article  Google Scholar 

  40. Gegner, J. A., Graham, D. R., Roth, A. F. & Dahlquist, F. W. Cell 70, 975–982 (1992).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK

    Dennis Bray

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  1. Dennis Bray
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Bray, D. Protein molecules as computational elements in living cells. Nature 376, 307–312 (1995). https://doi.org/10.1038/376307a0

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