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Fear conditioning induces associative long-term potentiation in the amygdala

An Erratum to this article was published on 19 February 1998

Abstract

Long-term potentiation (LTP) is an experience-dependent form of neural plasticity believed to involve mechanisms that underlie memory formation1,2,3. LTP has been studied most extensively in the hippocampus, but the relation between hippocampal LTP and memory has been difficult to establish4,5,6. Here we explore the relation between LTP and memory in fear conditioning, an amygdala-dependent form of learning in which an innocuous conditioned stimulus (CS) elicits fear responses after being associatively paired with an aversive unconditioned stimulus (US). We have previously shown that LTP induction in pathways that transmit auditory CS information to the lateral nucleus of the amygdala (LA) increases auditory-evoked field potentials in this nucleus7. Now we show that fear conditioning alters auditory CS-evoked responses in LA in the same way as LTP induction. The changes parallel the acquisition of CS-elicited fear behaviour, are enduring, and do not occur if the CS and US remain unpaired. LTP-like associative processes thus occur during fear conditioning, and these may underlie the long-term associative plasticity that constitutes memory of the conditioning experience.

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Figure 1: The effect of paired and unpaired training on CS-evoked field potentials and behaviour.
Figure 2: Scattergram of slope and amplitude values for each of the control and conditioned animals, before and after training.

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Acknowledgements

We thank D. Ringach for software development and M. Hou for histology and help with the surgical preparation of subjects.

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Correspondence to Michael T. Rogan.

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Rogan, M., Stäubli, U. & LeDoux, J. Fear conditioning induces associative long-term potentiation in the amygdala. Nature 390, 604–607 (1997). https://doi.org/10.1038/37601

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