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Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

Nature volume 374, pages 617–622 (1995)Cite this article

A Letter to this article was published on 18 May 1995

Abstract

Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3), which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization. These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal.

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Authors and Affiliations

  1. Varmus Laboratory, Bldg 49, Room 4A56, National Cancer Institute, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Xi He & Harold E. Varmus

  2. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Jean-Pierre Saint-Jeannet & Igor B. Dawid

  3. Ontario Cancer Institute, Toronto, Ontario, M4X 1K9, Canada

    James R. Woodgett

  4. Centre de Biologie du Developpement, UMR-CNRS 9925, Universite Paul Sabatier, 118 route de Narbonne, 31062, Toulouse cedex, France

    Jean-Pierre Saint-Jeannet

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  1. Xi He
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  2. Jean-Pierre Saint-Jeannet
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  4. Harold E. Varmus
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  5. Igor B. Dawid
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He, X., Saint-Jeannet, JP., Woodgett, J. et al. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374, 617–622 (1995). https://doi.org/10.1038/374617a0

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