Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation

Nature volume 374, pages 511–516 (1995)Cite this article

Abstract

c-mos protein, encoded by a proto-oncogene, is essential for the meiotic maturation of frog oocytes. Polyadenylation of c-mos messenger RNA is shown here to be a pivotal regulatory step in meiotic maturation. Maturation is prevented by selective amputation of polyadenylation signals from c-mos mRNA. Injection of a prosthetic RNA, which restores c-mos polyadenylation signals by base pairing to the amputated mRNA, rescues maturation and can stimulate translation in trans. Prosthetic RNAs may provide a general strategy by which to alter patterns of mRNA expression in vivo.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Yew, N., Strobel, M. & Vande Woude, G. F. Curr. Opin. Gen. Dev. 3, 19–25 (1993).

    Article  CAS  Google Scholar 

  2. Sagata, N., Daar, I., Oskarsson, M., Showalter, S. D. & Vande Woude, G. F. Science 245, 643–646 (1989).

    Article  ADS  CAS  Google Scholar 

  3. Freeman, R. S. Proc. natn. Acad. Sci. U.S.A. 86, 5805–5809 (1989).

    Article  ADS  CAS  Google Scholar 

  4. Yew, M., Mellini, M. I. & Vande Woude, G. F. Nature 355, 649–652 (1992).

    Article  ADS  CAS  Google Scholar 

  5. Colledge, W. H., Carlton, M. B. L., Udy, G. B. & Evans, M. J. Nature 370, 65–68 (1994).

    Article  ADS  CAS  Google Scholar 

  6. Hashimoto, N. et al. Nature 370, 68–71 (1994).

    Article  ADS  CAS  Google Scholar 

  7. Sagata, N., Oskarsson, M., Copeland, T., Brumbaugh, J. & Vande Woude, G. F. Nature 333, 519–525 (1988).

    Article  ADS  Google Scholar 

  8. Wickens, M. Semin devl Biol. 3, 399–412 (1992).

    Google Scholar 

  9. Jackson, R. & Standart, N. Cell 62, 15–24 (1990).

    Article  CAS  Google Scholar 

  10. Richter, J. Bioessays 13, 179–183 (1991).

    Article  CAS  Google Scholar 

  11. Fox, C. A., Sheets, M. D. & Wickens, M. P. Genes Dev. 3, 2151–2162 (1989).

    Article  CAS  Google Scholar 

  12. Sheets, M. D., Fox, C. A., Hunt, T., Vande Woude, G. & Wickens, M. Genes Dev. 8, 926–938 (1994).

    Article  CAS  Google Scholar 

  13. Smith, R. C. et al. Development 110, 769–779 (1990).

    CAS  PubMed  Google Scholar 

  14. Takayama, K. & Inouye, M. CRC Crit. Rev. Biochem. 25, 155–184 (1990).

    Article  CAS  Google Scholar 

  15. Nellen, W. & Lichtenstein, C. Trends biochem. Sci. 18, 419–423 (1993).

    Article  CAS  Google Scholar 

  16. Simons, R. W. & Kleckner, N. A. Rev. Genet. 22, 567–600 (1988).

    Article  CAS  Google Scholar 

  17. Bilger, A., Fox, C. A., Wahle, E. & Wickens, M. Genes Dev. 8, 1106–1116 (1994).

    Article  CAS  Google Scholar 

  18. Fox, C. A., Sheets, M., Wahle, E. & Wickens, M. EMBO J. 11, 5021–5032 (1992).

    Article  CAS  Google Scholar 

  19. Ballantyne, S., Bilger, A., Astrom, J., Virtanen, A. & Wickens, M. RNA (in the press).

  20. Maller, J. L. in Oogenesis Vol. 1 (ed. Browder, L. W.) 289–311 (Plenum, New York, 1985).

    Book  Google Scholar 

  21. Bachvarova, R. in Oogenesis Vol. 1 (ed. Browder, L. W.) 453–524 (Plenum, New York, 1985).

  22. Kobayashi, H. et al. J. Cell Biol. 114, 755–765 (1991).

    Article  CAS  Google Scholar 

  23. Wharton, R. & Struhl, G. Cell 67, 955–967 (1991).

    Article  CAS  Google Scholar 

  24. Ahringer, J. & Kimble, J. Nature 349, 346–348 (1991).

    Article  ADS  CAS  Google Scholar 

  25. Bass, B. & Weintraub, H. Cell 55, 1089–1098 (1988).

    Article  CAS  Google Scholar 

  26. Wagner, R. W., Smith, J. E., Cooperman, B. S. & Nishikura, K. Proc. natn. Acad. Sci. U.S.A. 86, 2647–2651 (1989).

    Article  ADS  CAS  Google Scholar 

  27. Bass, B. L. Semin. devl Biol. 3, 425–433 (1992).

    Google Scholar 

  28. Wickens, M. (ed.) Semin. devl Biol. 3, 363–424 (1992).

  29. Wickens, M. Nature 363, 305–306 (1993).

    Article  ADS  CAS  Google Scholar 

  30. Salles, F. J., Lieberfarb, M. E., Wreden, C., Gergen, J. P. & Strickland, S. Science 266, 1996–1998 (1994).

    Article  ADS  CAS  Google Scholar 

  31. Gebauer, F., Xu, M., Cooper, G. M. & Richter, J. D. EMBO J. 13, 5712–5720 (1994).

    Article  CAS  Google Scholar 

  32. Nishizawa, M., Okazaki, K., Furuno, N., Watanabe, N. & Sagata, N. EMBO J. 11, 2433–2446 (1992).

    Article  CAS  Google Scholar 

  33. Vande Woude, G. F. Nature 370, 20–21 (1994).

    Article  ADS  CAS  Google Scholar 

  34. Standart, N. & Jackson, R. Biochimie 76, 867–879 (1994).

    Article  CAS  Google Scholar 

  35. Konarska, M. M., Padgett, R. A. & Sharp, P. A. Cell 42, 165–171 (1985).

    Article  CAS  Google Scholar 

  36. Bienroth, S., Keller, W. & Wahle, E. EMBO J. 12, 585–594 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, 420 Henry Mall, College of Agriculture and Life Sciences, University of Wisconsin, Madison, Wisconsin, 53706, USA

    Michael D. Sheets & Marvin Wickens

  2. Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA

    Michael D. Sheets & Michael Wu

Authors
  1. Michael D. Sheets
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marvin Wickens
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sheets, M., Wu, M. & Wickens, M. Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation. Nature 374, 511–516 (1995). https://doi.org/10.1038/374511a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/374511a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing