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Abstract

The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarkably short (half-life ˜2 days). Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.

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Affiliations

  1. Division of Hematology/Oncology, University of Alabama at Birmingham, 613 Lyons-Harrison Research Building, 701 South 19th Street, Birmingham, Alabama, 35294, USA

    • Xiping Wei
    • , Sajal K. Ghosh
    • , Maria E. Taylor
    • , Beatrice H. Hahn
    •  & George M. Shaw
  2. Division of Infectious Diseases, University of Alabama at Birmingham, 613 Lyons-Harrison Research Building, 701 South 19th Street, Birmingham, Alabama, 35294, USA

    • Victoria A. Johnson
    •  & Michael S. Saag
  3. Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, 19486, USA

    • Emilio A. Emini
  4. Department of Clinical Pharmacology, Merck Research Laboratories, West Point, Pennsylvania, 19486, USA

    • Paul Deutsch
  5. Division of HIV and Exploratory Research, Genelabs Technologies Inc., Redwood City, California, 94063, USA

    • Jeffrey D. Lifson
  6. Department of Zoology, University of Oxford, Oxford, 0X1 3PS, UK

    • Sebastian Bonhoeffer
    •  & Martin A. Nowak

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https://doi.org/10.1038/373117a0

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