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Positional cloning of the mouse obese gene and its human homologue

Nature volume 372, pages 425–432 (1994)Cite this article

Abstract

The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation ofobresults in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.

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References

  1. Burros, M. Despite awareness of risks, more in US are getting fat in The New York Times 17 July 1994.

  2. Grundy, S. M. & Barnett, J. P. Disease-a-Month 36, 645–696 (1990).

    Article  Google Scholar 

  3. Friedman, J. M. & Leibel, R. L. Cell 69, 217–220 (1990).

    Article  Google Scholar 

  4. Ingalls, A. M., Dickie, M. M. & Snell, G. D. J. Hered. 41, 317–318 (1950).

    Article  CAS  PubMed  Google Scholar 

  5. Friedman, J. M. et al. Genomics 11, 1054–1062 (1991).

    Article  CAS  PubMed  Google Scholar 

  6. Coleman, D. L. Diabetologia 14, 141–148 (1978).

    Article  CAS  PubMed  Google Scholar 

  7. Dickie, M. M. & Lane, P. W. Mouse News Lett. 17, 52 (1957).

    Google Scholar 

  8. Bahary, N. et al. Mamm. Genome 4, 511–515 (1993).

    Article  CAS  PubMed  Google Scholar 

  9. Walther, C. et al. Genomics 11, 424–434 (1991).

    Article  CAS  PubMed  Google Scholar 

  10. Riley, J. et al. Nucleic Acids Res. 18, 2887–2890 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hermanson, G. G. et al. Nucleic Acids Res. 19, 4943–4948 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Sternberg, N. Trends Genet. 8, 11–16 (1992).

    Article  CAS  PubMed  Google Scholar 

  13. Hartl, D. L. & Nurminsky, D. I. BioTechniques 15, 201–208 (1993).

    PubMed  Google Scholar 

  14. Dietrich, W. et al. Genetics 131, 423–447 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Church, D. M. et al. Nature Genet. 6, 98–105 (1994).

    Article  CAS  PubMed  Google Scholar 

  16. Gish, W. & States, D. J. Nature Genet. 3, 266–272 (1993).

    Article  CAS  PubMed  Google Scholar 

  17. Kozak, M. Cell 44, 283–292 (1986).

    Article  CAS  PubMed  Google Scholar 

  18. Frohman, M. A., Dush, M. K. & Martin, G. R. Proc. natn. Acad. Sci. U.S.A. 85, 8998–9002 (1988).

    Article  ADS  CAS  Google Scholar 

  19. Padgett, R. A. et al. A. Rev. Biochem. 55, 1119–1150 (1986).

    Article  CAS  Google Scholar 

  20. Cooper, D. N. & Youssoufian, H. Hum. Genet. 78, 151–155 (1988).

    CAS  PubMed  Google Scholar 

  21. Heijne, G. v. Nucleic Acids Res. 14, 4683–4690 (1986).

    Article  Google Scholar 

  22. Sabatini, D. D. & Adesnick, M. B. The Metabolic Basis of Inherited Disease (eds Scriver, C. R. et al.) 177–223 (McGraw-Hill, New York, 1989).

    Google Scholar 

  23. Coleman, D. L. Science 203, 663–665 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Bray, G. A. Int. J. Obesity 14, 909–926 (1990).

    CAS  Google Scholar 

  25. Rubner, M. Ztschr. Biol. 30, 73–142 (1894).

    Google Scholar 

  26. Adolph, E. F. Am. J. Physiol. 151, 110–125 (1947).

    CAS  PubMed  Google Scholar 

  27. Hervey, G. R. Nature 222, 629–631 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Cannon, W. B. & Washburn, A. L. Am. J. Physiol. 29, 441–454 (1912).

    Google Scholar 

  29. Brobeck, J. R. Physiol. Rev. 25, 541–559 (1946).

    Article  Google Scholar 

  30. Hetherington, A. W. & Ranson, S. W. Am. J. Physiol. 136, 609–617 (1942).

    CAS  Google Scholar 

  31. Brobeck, J. R. Yale J. Biol. Med. 20, 545–552 (1948).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Kennedy, G. C. Proc. R. Soc. B 140, 578–592 (1953).

    ADS  CAS  Google Scholar 

  33. Mayer, J. Ann. N.Y. Acad. Sci. 63, 15–43 (1955).

    Article  ADS  CAS  PubMed  Google Scholar 

  34. Hervey, G. R. J. Physiol. 145, 336–352 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Bray, G. A. J. Nutrition 121, 1146–1162 (1991).

    Article  CAS  Google Scholar 

  36. Bahary, N. et al. Proc. natn. Acad. Sci. U.S.A. 87, 8642–8646 (1990).

    Article  ADS  CAS  Google Scholar 

  37. Neel, J. V. Am. J. hum. Genet. 14, 353–362 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Larin, Z., Monaco, A. P. & Lehrach, H. Proc. natn. Acad. Sci. U.S.A. 88, 4123–4127 (1991).

    Article  ADS  CAS  Google Scholar 

  39. Green, E. D. & Olson, M. V. Proc. natn. Acad. Sci. U.S.A. 87, 1213–1217 (1990).

    Article  ADS  CAS  Google Scholar 

  40. Kusuml, K. et al. Mamm. Genome 4, 391–392 (1993).

    Article  Google Scholar 

  41. Vidal, S. M. et al. Cell 73, 469–485 (1993).

    Article  CAS  PubMed  Google Scholar 

  42. Friedman, J. M. et al. Genomics 11, 1054–1062 (1991).

    Article  CAS  PubMed  Google Scholar 

  43. Chirgwin, J. M. et al. Biochemistry 18, 5294–5299 (1979).

    Article  CAS  PubMed  Google Scholar 

  44. Friedman, J. M., Cheng, E. & Darnell, J. E. J. molec Biol. 179, 37–53 (1984).

    Article  CAS  PubMed  Google Scholar 

  45. Wang, A. M., Doyle, M. V. & Mark, D. F. Proc. natn. Acad. Sci. U.S.A. 86, 9717–9721 (1989).

    Article  ADS  CAS  Google Scholar 

  46. Benton, W. D. & Davis, R. W. Science 195, 180–182 (1977).

    Article  ADS  Google Scholar 

  47. Burmeister, M. & Lehrach, H. Trends. Genet. 5, 41 (1989).

    Article  Google Scholar 

  48. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

  49. Venter, C. J. Automated DNA Sequencing and Analysis (Academic, New York, 1993).

    Google Scholar 

  50. Yu, Y. et al. Proc. natn. Acad. Sci. U.S.A. 86, 9931–9935 (1989).

    Article  ADS  CAS  Google Scholar 

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Author notes

  1. Jeffrey M. Friedman: To whom correspondence should be addressed.

Authors and Affiliations

  1. Howard Hughes Medical Institute, 1230 york avenue, New York, New York, 10021, USA

    Yiying Zhang, Ricardo Proenca, Marisa Barone, Lori Leopold & Jeffrey M. Friedman

  2. The Rockefeller University, 1230 york avenue, New York, New York, 10021, USA

    Yiying Zhang, Ricardo Proenca, Margherita Maffei, Marisa Barone, Lori Leopold & Jeffrey M. Friedman

Authors
  1. Yiying Zhang
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  2. Ricardo Proenca
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  3. Margherita Maffei
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  4. Marisa Barone
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  5. Lori Leopold
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  6. Jeffrey M. Friedman
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Zhang, Y., Proenca, R., Maffei, M. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432 (1994). https://doi.org/10.1038/372425a0

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  • DOI: https://doi.org/10.1038/372425a0

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