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Chromosomal translocations in human cancer

Nature volume 372, pages 143–149 (1994)Cite this article

Abstract

Chromosomal abnormalities in tumours were recognized at the end of the last century but their significance has only recently become clear. Distinct translocations in leukaemias and in solid tumours lead to the activation of protooncogene products or, more commonly, creation of tumour-specific fusion proteins. The proteins in both categories are often transcription factors and thus disruption of transcriptional control plays a major role in the aetiology of cancer. Fusion proteins formed after chromosomal translocations are common in a range of tumour types; these are unique tumour antigens and are therefore potential targets for therapy design.

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References

  1. Boveri, T. Zur Frage der Entstehung Maligner Tumoren (Fischer, Jena, Germany, 1914).

    Google Scholar 

  2. Rabbitts, T. H. & Boehm, T. Adv. Immun. 50, 119–146 (1991).

    CAS  PubMed  Google Scholar 

  3. Malcolm, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4957–4961 (1982).

    ADS  CAS  Google Scholar 

  4. Blackwood, E. M. & Eisenman, R. N. Science 251, 1211–1217 (1991).

    ADS  CAS  Google Scholar 

  5. Prendergast, G. C., Lawe, D. & Ziff, E. Cell 65, 395–407 (1991).

    CAS  Google Scholar 

  6. Ayer, D. E., Kretzner, L. & Eisenman, R. N. Cell 72, 211–222 (1993).

    CAS  Google Scholar 

  7. Zervos, A. S., Gyuris, J. & Brent, R. Cell 72, 223–232 (1993).

    CAS  Google Scholar 

  8. Amati, B. et al. Cell 72, 233–245 (1993).

    CAS  Google Scholar 

  9. Strasser, A. et al. Proc. natn. Acad. Sci. U.S.A. 88, 8661–8665 (1991).

    ADS  CAS  Google Scholar 

  10. Sentman, C. L., Shutter, J. R., Hockenberry, D., Kanagawa, O. & Korsmeyer, S. J. Cell 67, 879–888 (1991).

    CAS  Google Scholar 

  11. Strasser, A., Harris, A. W. & Cory, S. Cell 67, 889–899 (1991).

    CAS  Google Scholar 

  12. Hockenberry, D. M., Oitval, Z. N., Yin, X.-M., Milliman, C. L. & Korsmeyer, S. J. Cell 75, 241–251 (1993).

    Google Scholar 

  13. Kane, D. J. et al. Science 262, 1274–1277 (1993).

    ADS  CAS  Google Scholar 

  14. Korsmeyer, S. J., Shutter, J. R., Veis, D. J., Merry, D. E. & Oltvai, Z. N. Sem. Cancer Biol. 4, 327–332 (1993).

    CAS  Google Scholar 

  15. Dube, I. D. et al. Blood 78, 2996–3003 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Hatano, M., Roberts, C. W. M., Minden, M., Crist, W. M. & Korsmeyer, S. J. Science 253, 79–82 (1991).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  17. Kennedy, M. A. et al. Proc. natn. Acad. Sci. U.S.A. 88, 8900–8904 (1991).

    ADS  CAS  Google Scholar 

  18. Lu, M., Gong, Z., Shen, W. & Ho, A. D. EMBO J. 10, 2905–2910 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Dear, T. N., Sanchez-Garcia, I. & Rabbitts, T. H. Proc. natn. Acad. Sci. U.S.A. 90, 4431–4435 (1993).

    ADS  CAS  Google Scholar 

  20. Baer, R. Sem. Cancer Biol. 4, 341–347 (1993).

    CAS  Google Scholar 

  21. Hsu, H.-L., Cheng, J.-T., Chen, Q. & Baer, R. Molec. cell. Biol. 11, 3037–3042 (1991).

    CAS  PubMed  Google Scholar 

  22. Sanchez-Garcia, I. & Rabbitts, T. H. Sem. Cancer Biol. 4, 349–358 (1993).

    CAS  Google Scholar 

  23. Boehm, T., Foroni, L., Kennedy, M. & Rabbitts, T. H. Oncogene 5, 1103–1105 (1990).

    CAS  PubMed  Google Scholar 

  24. Perez-Alvarado, G. C. et al. Nature struct. Biol. 1, 388–398 (1994).

    CAS  PubMed  Google Scholar 

  25. Rabbitts, T. H. & Boehm, T. Nature 346, 418 (1990).

    ADS  CAS  PubMed  Google Scholar 

  26. Valge-Archer, V. E. et al. Proc. natn. Acad. Sci. U.S.A. 91, 8617–8621 (1994).

    ADS  CAS  Google Scholar 

  27. Wadman, I. et al. EMBO J. 3, 4831–4839 (1994).

    Google Scholar 

  28. Warren, A. J. et al. Cell 78, 45–58 (1994).

    CAS  PubMed  Google Scholar 

  29. Nowell, P. C. & Hungerford, D. A. Science 132, 1497 (1960).

    Google Scholar 

  30. Bartram, C. R. et al. Nature 306, 277–280 (1983).

    ADS  CAS  PubMed  Google Scholar 

  31. de Klein, A. et al. Blood 68, 1369–1375 (1986).

    CAS  PubMed  Google Scholar 

  32. Kamps, M. P., Murre, C., Sun, X.-H. & Baltimore, D. Cell 60, 547–555 (1990).

    CAS  PubMed  Google Scholar 

  33. Nourse, J. et al. Cell 60, 535–545 (1990).

    CAS  PubMed  Google Scholar 

  34. Ohki, M. Sem. Cancer Biol. 4, 369–376 (1993).

    CAS  Google Scholar 

  35. Laabi, Y. et al. EMRO J. 11, 3897–3904 (1992).

    CAS  Google Scholar 

  36. Golub, T. R., Barker, G. F., Lovett, M. & Gilliland, D. G. Cell 77, 307–316 (1994).

    CAS  PubMed  Google Scholar 

  37. Morris, S. W. et al. Science 263, 1281–1284 (1994).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  38. Mizuno, K. et al. Oncogene 9, 1605–1612 (1994).

    CAS  PubMed  Google Scholar 

  39. Gillard, E. F. & Solomon, E. Sem. Cancer Biol. 4, 359–368 (1993).

    CAS  Google Scholar 

  40. Chen, Z. et al. EMBO J. 12, 1161–1167 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  41. van Dijk, M. A., Voorhoeve, P. M. & Murre, C. Proc. natn. Acad. Sci. U.S.A. 90, 6061–6065 (1993).

    ADS  CAS  Google Scholar 

  42. Hunger, S. P., Ohyashiki, K., Toyama, K. & Cleary, M. L. Genes Dev. 6, 1608–1620 (1992).

    CAS  Google Scholar 

  43. Inaba, T. et al. Science 257, 531–534 (1992).

    ADS  CAS  Google Scholar 

  44. Djabali, M. et al. Nature Genet. 2, 113–118 (1992).

    CAS  PubMed  Google Scholar 

  45. Gu, Y. et al. Cell 71, 701–708 (1992).

    CAS  Google Scholar 

  46. Tkachuk, D. C., Kohler, S. & Cleary, M. L. Cell 71, 691–700 (1992).

    CAS  Google Scholar 

  47. Corral, J. et al. Proc. natn. Acad. Sci. U.S.A. 90, 8538–8542 (1993).

    ADS  CAS  Google Scholar 

  48. Pierotti, M. A. et al. Proc. natn. Acad. Sci. U.S.A. 89, 1616–1620 (1992).

    ADS  CAS  Google Scholar 

  49. Delattre, O. et al. Nature 359, 162–165 (1992).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  50. Crozat, A., Aman, P., Mandahl, N. & Ron, D. Nature 363, 640–644 (1993).

    ADS  CAS  PubMed  Google Scholar 

  51. Rabbitts, T. H., Forster, A., Larson, R. & Nathan, P. Nature Genet. 4, 175–180 (1993).

    CAS  PubMed  Google Scholar 

  52. Barr, F. G. et al. Nature Genet. 3, 113–117 (1993).

    CAS  PubMed  Google Scholar 

  53. Galili, N. et al. Nature Genet. 5, 230–235 (1993).

    CAS  PubMed  Google Scholar 

  54. Clark, J. et al. Nature Genet. 7, 502–5087 (1994).

    CAS  PubMed  Google Scholar 

  55. Ben-David, Y., Giddens, E. B., Letwin, K. & Bernstein, A. Genes Dev. 5, 908–918 (1991).

    CAS  PubMed  Google Scholar 

  56. Zucman, J. et al. EMBO J. 12, 4481–4487 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  57. May, W. A. et al. Proc. natn. Acad. Sci. USA. 90, 5752–5756 (1993).

    ADS  CAS  Google Scholar 

  58. Sorensen, P. H. B. et al. Nature Genet. 6, 146–151 (1994).

    CAS  PubMed  Google Scholar 

  59. Zucman, J. et al. Nature Genet. 4, 341–345 (1993).

    CAS  PubMed  Google Scholar 

  60. Mulligan, L. M. et al. Nature 363, 458–460 (1993).

    ADS  CAS  Google Scholar 

  61. Shimizu, K. et al. Proc. natn. Acad. Sci. U.S.A. 90, 10280–10284 (1993).

    ADS  CAS  Google Scholar 

  62. Ron, D. & Habener, J. F. Genes Dev. 6, 439–453 (1992).

    CAS  Google Scholar 

  63. Sanchez-Garcia, I. & Rabbins, T. H. Proc. natn. Acad. Sci. U.S.A. 91, 7869–7873 (1994).

    ADS  CAS  Google Scholar 

  64. Maulbecker, C. C. & Gruss, P. EMBO J. 12, 2361–2367 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  65. Rowley, J. D. Genes Chrom. Cancer 5, 264–266 (1992).

    CAS  PubMed  Google Scholar 

  66. Shima, E. A. et al. Proc. natn. Acad. Sci. U.S.A. 83, 3439–3443 (1986).

    ADS  CAS  Google Scholar 

  67. Rimokh, R. et al. Genes Chrom. Cancer 3, 24–36 (1991).

    CAS  PubMed  Google Scholar 

  68. Mellentin, J. D., Smith, S. D. & Cleary, M. L. Cell 58, 77–83 (1989).

    CAS  PubMed  Google Scholar 

  69. Kerckaert, J.-P. et al. Nature Genet. 5, 66–70 (1993).

    CAS  PubMed  Google Scholar 

  70. Ye, B. H. et al. Science 262, 747–750 (1993).

    ADS  CAS  PubMed  Google Scholar 

  71. Gauwerky, C. E. & Croce, C. M. Sem. Cancer Biol. 4, 333–340 (1993).

    CAS  Google Scholar 

  72. Mengle-Gaw, L. et al. EMBO J. 6, 2273–2280 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Neri, A. et al. Cell 67, 1075–1087 (1991).

    CAS  PubMed  Google Scholar 

  74. Ohno, H., Takimoto, G. & McKeithan, T. W. Cell 60, 991–997 (1990).

    CAS  PubMed  Google Scholar 

  75. Wulczyn, F. G., Naumann, M. & Scheidereit, C. Nature 358, 597–599 (1992).

    ADS  CAS  PubMed  Google Scholar 

  76. Kerr, L. D. et al. Genes Dev. 6, 2352–2363 (1992).

    CAS  PubMed  Google Scholar 

  77. Grimaldi, J. C. & Meeker, T. C. Blood 73, 2081–2085 (1989).

    CAS  Google Scholar 

  78. Meeker, T. C., Hardy, D., Willman, C., Hogan, T. & Abrams, J. Blood 76, 285–289 (1990).

    CAS  PubMed  Google Scholar 

  79. Ellisen, L. W. et al. Cell 66, 649–661 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  80. Burnett, R. C. et al. Genes Chrom. Cancer 3, 461–467 (1991).

    CAS  PubMed  Google Scholar 

  81. Tycko, B., Smith, S. D. & Sklar, J. J. exp. Med. 174, 867–873 (1991).

    CAS  PubMed  Google Scholar 

  82. Fisch, P., Forster, A., Sherrington, P. D., Dyer, M. J. S. & Rabbitts, T. H. Oncogene 8, 3271–3276 (1993).

    CAS  PubMed  Google Scholar 

  83. Stern, M.-H. et al. Oncogene 8, 2475–2483 (1993).

    CAS  PubMed  Google Scholar 

  84. Baer, R., Chen, K.-C., Smith, S. D. & Rabbitts, T. H. Cell 43, 705–713 (1985).

    CAS  PubMed  Google Scholar 

  85. Denny, C. T. et al. Nature 320, 549–551 (1986).

    ADS  CAS  PubMed  Google Scholar 

  86. de Klein, A. et al. Nature 300, 765–767 (1982).

    ADS  CAS  PubMed  Google Scholar 

  87. Nakamura, T. et al. Proc. natn. Acad. Sci. U.S.A. 90, 4631–4635 (1993).

    ADS  CAS  Google Scholar 

  88. lida, S. et al. Oncogene 8, 3085–3092 (1993).

    Google Scholar 

  89. Yamamoto, K. et al. Oncogene 8, 2617–2625 (1993).

    CAS  PubMed  Google Scholar 

  90. Bernard, O. A., Mauchauffe, M., Mecucci, C., Van Den Berghe, H. & Berger, R. Oncogene 9, 1039–1045 (1994).

    CAS  PubMed  Google Scholar 

  91. Prasad, R. et al. Cancer Res. 53, 5624–5628 (1993).

    CAS  PubMed  Google Scholar 

  92. Prasad, R. et al. Proc. natn. Acad. Sci. U.S.A. 91, 8107–8111 (1994).

    ADS  CAS  Google Scholar 

  93. Mitani, K. et al. EMBO J. 13, 504–510 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  94. Nucifora, G., Begy, C. R., Erickson, P., Drabkin, H. A. & Rowley, J. D. Proc. natn. Acad. Sci. U.S.A. 90, 7784–7788 (1993).

    ADS  CAS  Google Scholar 

  95. von Lindern, M. et al. Molec. cell. Biol. 12, 1687–1697 (1992).

    CAS  PubMed  Google Scholar 

  96. von Lindern, M., Breems, D., van Baal, S., Adriaansen, H. & Grosveld, G. Genes Chrom. Cancer 5, 227–234 (1992).

    CAS  PubMed  Google Scholar 

  97. Lu, D. et al. Oncogene 6, 1235–1241 (1991).

    CAS  PubMed  Google Scholar 

  98. Liu, P. et al. Science 261, 1041–1044 (1993).

    ADS  CAS  PubMed  Google Scholar 

  99. Ichikawa, H., Shimizu, K., Hayashi, Y. & Ohki, M. Cancer Res. 54, 2865–2868 (1994).

    CAS  PubMed  Google Scholar 

  100. Panagopoulos, I. et al. Genes Chrom. Cancer (in the press).

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    T. H. Rabbitts

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Rabbitts, T. Chromosomal translocations in human cancer. Nature 372, 143–149 (1994). https://doi.org/10.1038/372143a0

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