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Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor

Nature volume 370, pages 216–218 (1994)Cite this article

An Erratum to this article was published on 04 August 1994

Abstract

PLATELET-ACTIVATING factor (PAF) is involved in a variety of biological and pathological processes1 and PAF acetylhydrolase, which inactivates PAF by removing the acetyl group at the sn-2 position, is widely distributed in plasma and tissue cytosols2,3. One isoform of PAF acetylhydrolase present in bovine brain cortex is a heterotrimer comprising subunits with relative molecular masses of 45K, 30K and 29K (ref. 4). We have now isolated the comple-mentary DNA for the 45K subunit. Sequence analysis revealed a striking identity (99%) of the subunit with a protein encoded by the causative gene (LIS-1) for Miller-Dieker lissencephaly5, a human brain malformation manifested by a smooth cerebral surface and abnormal neuronal migration. This indicates that the LIS-1 gene product is a human homologue of the 45K subunit of intracellular PAF acetylhydrolase. Our results raise the possibility that PAF and PAF acetylhydrolase are important in the formation of the brain cortex during differentiation and development.

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References

  1. Hanahan, D. J. A. Rev. Biochem. 55, 483–509 (1986).

    Article  CAS  Google Scholar 

  2. Stafforini, D. M., Prescott, S. M. & Mclntyre, T. M. J. biol. Chem. 262, 4223–4230 (1987).

    CAS  PubMed  Google Scholar 

  3. Farr, R. S., Cox, C. P., Wardlow, M. L. & Jorgensen, R. Clin. Immun. Immunopath. 15, 318–330 (1980).

    Article  CAS  PubMed  Google Scholar 

  4. Hattori, M., Arai, H. & Inoue, K. J. biol. Chem. 288, 18748–18753 (1993).

    Google Scholar 

  5. Reiner, O. et al. Nature 364, 717–721 (1993).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Shaw, G. & Kamen, R. Cell 46, 659–667 (1986).

    Article  CAS  PubMed  Google Scholar 

  7. van dern Voorn, L. & Ploegh, H. L. FEBS Lett. 507, 131–134 (1992).

    Article  Google Scholar 

  8. Ledbetter, S. A., Kuwano, A., Dobyns, W. B. & Ledbetter, D. H. Am. J. hum. Genet. 50, 182–189 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Dynlacht, B. D., Weinzierl, R. O. J., Admon, A. & Tjian, R. Nature 363, 176–179 (1993).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Sogos, V., Bussolino, F., Pilia, E., Torelli, S. & Gremo, F. J. Neurosci. Res. 27, 706–711 (1990).

    Article  CAS  PubMed  Google Scholar 

  11. Honda, Z. et al. Nature 349, 342–345 (1991).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Bito, H. et al. Neuron 9, 285–294 (1992).

    Article  CAS  PubMed  Google Scholar 

  13. Catalan, R. E. et al. Biochem. biophys. Res. Commun. 183, 300–305 (1992).

    Article  CAS  PubMed  Google Scholar 

  14. Kato, K., Clark, G. D., Bazen, N. G. & Zorumski, C. F. Nature 367, 175–179 (1994).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Dobyns, W. B., Reiner, O., Carrozo, R. & Ledbetter, D. H. J. Am. med. Ass. 270, 2838–2842 (1993).

    Article  CAS  Google Scholar 

  16. Kornecki, E. & Ehrlich, Y. H. Science 240, 1792–1794 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Isola, N. R., Harn, H. J. & Cooper, D. L. BioTechniques 11, 580–582 (1991).

    CAS  PubMed  Google Scholar 

  18. Kwiatkowski, T. J., Zoghbi, H. Y., Ledbetter, S. A., Ellison, K. A. & Chinault, A. C. Nucleic Acids Res. 18, 7191–7192 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Health Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113, Japan

    Mitsuharu Hattori, Hiroyuki Arai & Keizo Inoue

  2. Suntory Institute for Biomedical Research, Mishima, Osaka, 618, Japan

    Hideki Adachi & Masafumi Tsujimoto

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  1. Mitsuharu Hattori
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  2. Hideki Adachi
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  3. Masafumi Tsujimoto
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  4. Hiroyuki Arai
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  5. Keizo Inoue
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Hattori, M., Adachi, H., Tsujimoto, M. et al. Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor. Nature 370, 216–218 (1994). https://doi.org/10.1038/370216a0

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