Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Progress
  • Published:

Vesicle fusion from yeast to man

Abstract

Membrane budding and fusion occur in all eukaryotic cells. Their underlying mechanisms have been studied in mammalian neurons and in yeast, a simple eukaryote. The differences between these two systems would suggest that fusion events in yeast and the neuron would operate by different mechanisms, but recent advances indicate that this is not true.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. White, J. M. Science 258, 917–923 (1992).

    Article  ADS  CAS  Google Scholar 

  2. Shim, J., Newman, A. & Ferro-Novick, S. J. Cell Biol. 113, 55–64 (1991).

    Article  CAS  Google Scholar 

  3. Protopopov, V., Govindan, B., Novick, P. & Gerst, J. E. Cell 74, 855–861 (1993).

    Article  CAS  Google Scholar 

  4. Aalto, M. K., Ronne, H. & Keranen, S. EMBO J. 12, 4095–4104 (1993).

    Article  CAS  Google Scholar 

  5. Lian, J. P. & Ferro-Novick, S. Cell 73, 735–745 (1993).

    Article  CAS  Google Scholar 

  6. Schiavo, G. et al. Nature 359, 832–835 (1992).

    Article  ADS  CAS  Google Scholar 

  7. Link, E. et al. Biochem. biophys. Res. Commun. 189, 1017–1023 (1992).

    Article  CAS  Google Scholar 

  8. Blasi, J. et al. Nature 365, 160–163 (1993).

    Article  ADS  CAS  Google Scholar 

  9. Blasi, J. et al. EMBO J. 12, 4821–4828 (1993).

    Article  CAS  Google Scholar 

  10. Schiavo, G. et al. J. biol. Chem. 268, 23784–23787 (1993).

    CAS  PubMed  Google Scholar 

  11. Söllner, T. et al. Nature 362, 318–324 (1993).

    Article  ADS  Google Scholar 

  12. Block, M. R., Glick, B. S., Wilcox, C. A., Wieland, F. T. & Rothman, J. E. Proc. natn. Acad. Sci. U.S.A. 85, 7852–7856 (1988).

    Article  ADS  CAS  Google Scholar 

  13. Clary, D. O. & Rothman, J. E. J. biol. Chem. 265, 10109–10117 (1990).

    CAS  Google Scholar 

  14. Wilson, D. W. et al. Nature 339, 355–359 (1989).

    Article  ADS  CAS  Google Scholar 

  15. Clary, D. O., Griff, L. C. & Rothman, J. E. Cell 61, 709–721 (1990).

    Article  CAS  Google Scholar 

  16. Griff, I. E., Schekman, R., Rothman, J. E. & Kaiser, C. A. J. biol. Chem. 267, 12106–12115 (1992).

    CAS  PubMed  Google Scholar 

  17. Graham, T. R. & Emr, S. D. J. Cell Biol. 114, 207–218 (1991).

    Article  CAS  Google Scholar 

  18. Söllner, T. et al. Cell 75, 409–418 (1993).

    Article  Google Scholar 

  19. Jessell, T. M. & Kandel, E. Cell 72 (suppl.), 1–30 (1993).

    Article  Google Scholar 

  20. Diaz, R., Mayorga, L. S., Weidman, P. J., Rothman, J. E. & Stahl, P. D. Nature 339, 398–400 (1991).

    Article  ADS  Google Scholar 

  21. Link, E. et al. J. biol. Chem. 268, 18423–18426 (1993).

    CAS  PubMed  Google Scholar 

  22. Pryer, N. K., Wuestehube, L. J. & Schekman, R. A. Rev. Biochem. 61, 471–516 (1992).

    Article  CAS  Google Scholar 

  23. Novick, P., Field, C. & Schekman, R. Cell 21, 205–215 (1980).

    Article  CAS  Google Scholar 

  24. Novick, P., Ferro, S. & Schekman, R. Cell 25, 461–469 (1981).

    Article  CAS  Google Scholar 

  25. Wood, W. G. et al. The Nematode Caenorhabditis elegans (Cold Spring Harbor Laboratory Press, New York, 1988).

    Google Scholar 

  26. McMahon, H. et al. Nature 364, 356–359 (1993).

    Article  ADS  Google Scholar 

  27. Bennett, M. K. et al. Cell 74, 863–873 (1993).

    Article  CAS  Google Scholar 

  28. Gerst, J. E., Rodgers, L., Riggs, M. & Wigler, M. Proc. natn. Acad. Sci. U.S.A. 89, 4338–4342 (1992).

    Article  ADS  CAS  Google Scholar 

  29. Newman, A., Shim, J. & Ferro-Novick, S. Molec. cell. Biol. 10, 3405–3414 (1990).

    Article  CAS  Google Scholar 

  30. Newman, A., Groesch, M. & Ferro-Novick, S. EMBO J. 12, 3609–3617 (1992).

    Article  Google Scholar 

  31. Simpson, L. L. (ed.) Botulinum neurotoxin and Tetanus neurotoxin (Academic, New York, 1989).

  32. Niemann, H. Sourcebook of Bacterial Toxins (eds Alouf, J. E. & Freer, J. H.) 303–348 (Academic, New York, 1991).

    Google Scholar 

  33. Binz, T. et al. J. biol. Chem. 269, 1617–1620 (1994).

    CAS  PubMed  Google Scholar 

  34. Osen-Sand, A. et al. Nature 364, 445–448 (1993).

    Article  ADS  CAS  Google Scholar 

  35. Oyler, G. A. et al. J. Cell Biol. 109, 3039–3052 (1989).

    Article  CAS  Google Scholar 

  36. Bennett, M. K., Calakos, N. & Scheller, R. H. Science 257, 255–259 (1992).

    Article  ADS  CAS  Google Scholar 

  37. Inoue, A., Obata, K. & Akagawa, K. J. biol. Chem. 267, 10613–10619 (1992).

    CAS  Google Scholar 

  38. Yoshida, A. et al. J. biol. Chem. 267, 24925–24928 (1992).

    CAS  Google Scholar 

  39. Brose, N., Petrenko, A. G., Südhof, T. C. & Jahn, R. Science 256, 1021–1025 (1992).

    Article  ADS  CAS  Google Scholar 

  40. Nonet, M. L., Grundahl, K., Meyer, B. J. & Rand, J. B. Cell 73, 1291–1305 (1993).

    Article  CAS  Google Scholar 

  41. DiAntonio, A. D., Parfitt, K. D. & Schwarz, T. L. Cell 73, 1281–1290 (1993).

    Article  CAS  Google Scholar 

  42. Littleton, J. T. et al. Cell 74, 1125–1134 (1993).

    Article  CAS  Google Scholar 

  43. Bommert, K. et al. Nature 363, 163–165 (1993).

    Article  ADS  CAS  Google Scholar 

  44. Hardwick, K. G. & Pelham, H. R. B. J. Cell Biol. 119, 513–521 (1992).

    Article  CAS  Google Scholar 

  45. Becherer, K. A. & Jones, E. W. EMBL Data Bank Rel. 31, M90395 (1992).

  46. Ferro-Novick, S. & Novick, P. A. Rev. Cell Biol. 9, 575–599 (1993).

    Article  CAS  Google Scholar 

  47. Brennwald, P. & Novick, P. Nature 362, 560–563 (1993).

    Article  ADS  CAS  Google Scholar 

  48. Dunn, B., Stearns, T. & Botstein, D. Nature 362, 563–565 (1993).

    Article  ADS  CAS  Google Scholar 

  49. Dascher, C., Rainer, O., Gallwitz, D. & Schmitt, H. D. Molec. cell. Biol. 11, 872–885 (1991).

    Article  CAS  Google Scholar 

  50. Ossig, R. et al. Molec. cell. Biol. 11, 2980–2993 (1991).

    Article  CAS  Google Scholar 

  51. Aalto, M. K., Keranen, S. & Ronne, H. Cell 68, 181–182 (1992).

    Article  CAS  Google Scholar 

  52. Banta, L., Vida, T., Herman, P. & Emr, S. D. Molec. cell. Biol. 10, 4638–4649 (1990).

    Article  CAS  Google Scholar 

  53. Hata, Y., Slaughter, C. A. & Südhof, T. C. Nature 366, 347–351 (1993).

    Article  ADS  CAS  Google Scholar 

  54. Garcia, E. P. et al. Proc. natn. Acad. Sci. U.S.A. 91, 2003–2007 (1994).

    Article  ADS  CAS  Google Scholar 

  55. Bennett, M. K. & Scheller, R. H. Proc. natn. Acad. Sci. U.S.A. 90, 2559–2563 (1993).

    Article  ADS  CAS  Google Scholar 

  56. Warren, G. Nature 362, 397–398 (1993).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ferro-Novick, S., Jahn, R. Vesicle fusion from yeast to man. Nature 370, 191–193 (1994). https://doi.org/10.1038/370191a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/370191a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing