Melanocortin receptors in leptin effects

Abstract

Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4. We now show that MC4 receptor signalling is an important mediator of leptin's effects on food intake and body weight, demonstrating a link between the two systems.

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Figure 1: Effect of treatment with a melanocortin receptor antagonist on feeding and the leptin response (means±s.e.m.).

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