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Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs


THE c-mos proto-oncogene encodes a 37-39K cytoplasmic serine/ threonine kinase1 implicated in the meiotic maturation events during murine spermatogenesis2 and oogenesis3–6. In Xenopus, ectopic expression of pp39mos can promote both the meiotic matur-ation of oocytes7–9 and also arrest the cleavage of blastomeres10. To elucidate the role of pp39mos we have generated homozygous mutant mice by gene targeting in embryonic stem cells11. These mice are viable and mutant males are fertile, demonstrating that pp39mos is not essential for spermatogenesis. In contrast, mutant females, have a reduced fertility because of the failure of mature eggs to arrest during meiosis. c-mos-/- oocytes undergo germinal vesicle breakdown and extrusion of both polar bodies followed in some cases by progression into cleavage. Mutant females also develop ovarian cysts. These results demonstrate that a major role for pp39mos is to prevent the spontaneous parthenogenetic activation of unfertilized eggs.

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  1. Maxwell, S. & Arlinghaus, R. B. Virology 143, 321–333 (1985).

    Article  CAS  Google Scholar 

  2. Propst, F. et al. Oncogene 2, 227–233 (1988).

    CAS  PubMed  Google Scholar 

  3. Paules, R. S. et al. Proc. natn. Acad. Sci. U.S.A. 86, 5395–5399 (1989).

    Article  CAS  ADS  Google Scholar 

  4. Zhao, X., Batten, B., Singh, B. & Arlinghaus, R. B. Oncogene 5, 1727–1730 (1990).

    CAS  PubMed  Google Scholar 

  5. Mutter, G. L., Grills, G. S. & Wogemuth, D. J. EMBO J. 7, 683–689 (1988).

    Article  CAS  Google Scholar 

  6. O'Keefe, S. J., Wolfes, H., Kiessling, A. A. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 86, 7038–7042 (1989).

    Article  CAS  ADS  Google Scholar 

  7. Sagata, N., Daar, I., Oskarsson, M., Showalter, S. D. & Vande Woude, G. F. Science 245, 643–646 (1989).

    Article  CAS  ADS  Google Scholar 

  8. Freeman, R. S. Proc. natn. Acad. Sci. U.S.A. 86, 5805–5809 (1989).

    Article  CAS  ADS  Google Scholar 

  9. Yew, N., Mellini, M. I. & Vande Woude, G. F. Nature 355, 649–652 (1992).

    Article  CAS  ADS  Google Scholar 

  10. Sagata, N., Watanabe, N., Vande Woude, G. F. & Ikawa, Y. Nature 342, 512–518 (1989).

    Article  CAS  ADS  Google Scholar 

  11. Bradley, A. Curr. Opinion Biotech. 2, 823–829 (1991).

    Article  CAS  Google Scholar 

  12. Hanks, S. K., Quinn, A. M. & Hunter, T. Science 241, 42–52 (1988).

    Article  CAS  ADS  Google Scholar 

  13. Singh, B., Hannink, M., Donoghue, D. J. & Arlinghaus, R. B. J. Virol. 60, 1148–1152 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Eppig, J. J. & Telfer, E. E. Meth. Enzym. 225, 77–84 (1993).

    Article  CAS  Google Scholar 

  15. Watanabe, N., Vande Woude G. F., Ikawa, Y. & Sagata, N. Nature 342, 505–511 (1989).

    Article  CAS  ADS  Google Scholar 

  16. Weber, M., Kubiak, J. Z., Arlinghaus, R. B., Pines, J. & Maro, B. Devl Biol. 148, 393–397 (1991).

    Article  CAS  Google Scholar 

  17. Watanabe, N., Hunt, T., Ikawa, Y. & Sagata, N. Nature 352, 247–248 (1991).

    Article  CAS  ADS  Google Scholar 

  18. Kaufman, M. H. & Howlett S. K. Gamete Res. 14, 255–264 (1986).

    Article  Google Scholar 

  19. Talerman, A. Curr. Top. Pathol. 85, 165–202 (1992).

    Article  CAS  Google Scholar 

  20. Wood, T. G., McGeady, M. L., Baroudy, B. M., Blair, D. G. & Vande Woude, G. C. Proc. natn. Acad. Sci. U.S.A. 81, 7817–7821 (1984).

    Article  CAS  ADS  Google Scholar 

  21. Adra, C. N., Boer, P. H. & McBurney, M. W. Gene 60, 65–74 (1987).

    Article  CAS  Google Scholar 

  22. Ratcliff, R. et al. Nature Genet. 4, 35–11 (1993).

    Article  CAS  Google Scholar 

  23. Hogan, B., Constantini, F. & Lacy, E. Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Laboratory Press, New York, 1986).

    Google Scholar 

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Colledge, W., Carlton, M., Udy, G. et al. Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs. Nature 370, 65–68 (1994).

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