Figure 3 | Laboratory Investigation

Figure 3

From: Clonal evolution of lymphoblastoid cell lines

Figure 3

EBV DNA becomes clonal within 8 weeks in cultured lymphocytes. Southern blot analysis of EBV DNA was performed using a probe for the terminal repeat fragment. The upper panel shows the blot and the lower panel shows the corresponding gel stained with ethidium bromide. The Raji cell line controls depict monoclonality at levels of 50 copies, five copies, and one copy of EBV DNA per cell. The subsequent sets of four lanes each represent the five LCL samples at weeks 1, 2, 4, and 8. In each LCL, there is progression to a more restricted band pattern over time.

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