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c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

Nature volume 369, pages 571–574 (1994)Cite this article

Abstract

MEGAKARYOCYTOPOIESIS is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors1,2, and the second, thrombopoietin, is a megakaryocyte maturation factor3. Neither of these factors has been fully characterized. The proto-oncogene c-mpl, an orphan member of the haematopoietin receptor family4–6, is specifically involved in megakaryocyte regulation7. Here we present evidence that the c-mpl-encoded receptor binds a ligand (c-Mpl ligand) which is a humoral factor implicated in platelet homeostasis. Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule.

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References

  1. Williams, N., Eger, R. R., Jackson, H. M. & Nelson, D. J. J. Cell Physiol. 110, 101–104 (1982).

    CAS  Article  Google Scholar 

  2. Hoffman, R. Blood 74, 1196–1212 (1989).

    CAS  PubMed  Google Scholar 

  3. McDonald, T. P. Expl Hematol. 16, 201–205 (1988).

    CAS  Google Scholar 

  4. Skoda, R. C. et al. EMBO J. 12, 2645–2653 (1993).

    CAS  Article  Google Scholar 

  5. Vigon, I. et al. Proc. natn. Acad. Sci. U.S.A. 89, 5640–5644 (1992).

    ADS  CAS  Article  Google Scholar 

  6. Vigon, I. et al. Oncogene 8, 2607–2615 (1993).

    CAS  PubMed  Google Scholar 

  7. Methia, N., Louache, F., Vainchenker, W. & Wendiing, F. Blood 82, 1395–1401 (1993).

    CAS  PubMed  Google Scholar 

  8. Palacios, R. & Steinmetz, M. Cell 41, 727–734 (1985).

    CAS  Article  Google Scholar 

  9. Mazur, E. M. et al. Blood 76, 290–297 (1990).

    CAS  PubMed  Google Scholar 

  10. Hoffman, R., Yang, H. H., Bruno, E. & Straneva, J. E. J. clin. Invest. 75, 1174–1182 (1985).

    CAS  Article  Google Scholar 

  11. McDonald, T. P. Proc. Soc. exp. Biol. Med. 144, 1006–1011 (1973).

    CAS  Article  Google Scholar 

  12. Metcalf, D. In The Hematopoietic Colony Stimulating Factors 124–130 (Elsevier Science, Amsterdam, New York, Oxford, 1984).

    Google Scholar 

  13. Mazur, E. M. & South, K. Expl Hematol. 13, 1164–1172 (1985).

    CAS  Google Scholar 

  14. Debili, N. et al. Blood 82, 84–95 (1993).

    CAS  PubMed  Google Scholar 

  15. Russell, S. M. et al. Science 262, 1880–1883 (1993).

    ADS  CAS  Article  Google Scholar 

  16. Kondo, M. et al. Science 262, 1874–1877 (1993).

    ADS  CAS  Article  Google Scholar 

  17. Namen, A. E. et al. Nature 333, 571–573 (1988).

    ADS  CAS  Article  Google Scholar 

  18. Hopp, T. P. et al. Biotechnology 6, 1204–1210 (1988).

    CAS  Article  Google Scholar 

  19. Goodwin, R. G. et al. Eur. J. Immun. 23, 2631–2641 (1993).

    CAS  Article  Google Scholar 

  20. Ziegler, S. F. et al. New Biol. 3, 1242–1248 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Brizzard, B. L., Chubet, R. G. & Vizard, D. L. Biotechniques 16, 730–734 (1994).

    CAS  PubMed  Google Scholar 

  22. McMahan, C. J. et al. EMBO J. 10, 2821–2832 (1991).

    CAS  Article  Google Scholar 

  23. Fanslow, W. C., Anderson, D. M., Grabstein, K. H., Clark, E. A. & Cosman, D. J. Immun. 149, 655–660 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

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Affiliations

  1. INSERM U362, Institut Gustave Roussy, 94805, Villejuif, France

    Françoise Wendling, Najet Debili, Monique Titeux, Nassia Methia & William Vainchenker

  2. Immunex Corporation, 51 University Street, Seattle, Washington, 98101, USA

    Eugene Maraskovsky, Christina Florindo, Mark Teepe & David Cosman

  3. INSERM U91, Hôpital Henri Mondor, 94010, Créteil, France

    Janine Breton-Gorius

Authors
  1. Françoise Wendling
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  2. Eugene Maraskovsky
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  3. Najet Debili
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  4. Christina Florindo
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  5. Mark Teepe
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  6. Monique Titeux
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  7. Nassia Methia
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  8. Janine Breton-Gorius
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  9. David Cosman
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  10. William Vainchenker
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Wendling, F., Maraskovsky, E., Debili, N. et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369, 571–574 (1994). https://doi.org/10.1038/369571a0

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  • DOI: https://doi.org/10.1038/369571a0

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