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A two-component system that regulates an osmosensing MAP kinase cascade in yeast

Nature volume 369, pages 242–245 (1994)Cite this article

Abstract

IN the prokaryotic two-component signal transduction systems, recognition of an environmental stimulus by a sensor molecule results in the activation of its histidine kinase domain and phosphorylation of a histidine residue within that domain1–3. This phosphate group is then transferred to an aspartate residue in the receiver domain of a cognate response regulator molecule, resulting in the activation of its output function. Although a few eukaryotic proteins were identified recently that show sequence similarity to the prokaryotic sensors or response regulators, it has not been clear whether they constituted a part of a 'two-component' system4–7. Here we describe a two-component system in Saccharomyces cerevisiae that regulates an osmosensing MAP kinase cascade8,9.

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Author information

Author notes

  1. Haruo Saito: To whom correspondence should be addressed.

Affiliations

  1. Division of Tumor Immunology, Dana-Farber Cancer Institute, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Tatsuya Maeda, Susannah M. Wurgler-Murphy & Haruo Saito

Authors
  1. Tatsuya Maeda
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  2. Susannah M. Wurgler-Murphy
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  3. Haruo Saito
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Maeda, T., Wurgler-Murphy, S. & Saito, H. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369, 242–245 (1994). https://doi.org/10.1038/369242a0

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