Abstract
BACTERIAL colonies must often cope with unfavourable environmental conditions1,2. To do so, they have developed sophisticated modes of cooperative behaviour3–10. It has been found that such behaviour can cause bacterial colonies to exhibit complex growth patterns similar to those observed during non-equilibrium growth processes in non-living systems11; some of the qualitative features of the latter may be invoked to account for the complex patterns of bacterial growth12–18. Here we show that a simple model of bacterial growth can reproduce the salient features of the observed growth patterns. The model incorporates random walkers, representing aggregates of bacteria, which move in response to gradients in nutrient concentration and communicate with each other by means of chemotactic 'feedback'. These simple features allow the colony to respond efficiently to adverse growth conditions, and generate self-organization over a wide range of length scales.
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References
Stainer, R. Y., Doudoroff, M. & Adelberg, E. A. The Microbial World (Prentice-Hall, New Jersey, 1957).
Shapiro, J. A. Scientific American 258 (6) 62–69 (1988).
Shapiro, J. A. & Trubatch, D. Physica D49, 214–223 (1991).
Budrene, E. O. & Berg, H. C. Nature 349, 630–633 (1991).
Kessler, J. O. Contemp. Phys. 26, 147–166 (1985).
Adler, J. Science 166, 1588–1597 (1969).
Lackiie, J. M. (ed.) Biology of the Chemotactic Response (Cambridge Univ. Press, 1981).
Devreotes, P. Science 245, 1054–1058 (1989).
Berg, H. C. & Purcell, E. M. Biophys. J. 20, 193–219 (1977).
Nossal, R. Expl Cell Res. 75, 138–142 (1972).
Ben-Jacob, E. & Garik, P. Nature 343, 523–530 (1990).
Ben-Jacob, E., Shmueli, H., Shochet, O. & Tenenbaum, A. Physica A187, 378–424 (1992).
Ben-Jacob, E., Tenenbaum, A., Shochet, O. & Avidan, O. Physica A202, 1–47 (1994).
Henrici, T. H. The Biology of Bacteria 3rd edn (Heath, Boston, 1948).
Cooper, A. L. Proc. R. Soc. B 171, 175–199 (1968).
Fujikawa, H. & Matsushita, M. J. phys. Soc. Japan 58, 3875–3878 (1989).
Matsuyama, T. & Matsushita, M. Crit. Rev. Bact. 19, 117–135 (1993).
Schindler, J. & Rataj, T. Binary 4, 66–72 (1992).
Allison, C. & Hughes, C. Sci. Prog. 75, 403–422 (1991).
Henrichsen, J. Bacter. Rev. 36, 478–503 (1972).
Kessler, D. & Levine, H. Phys. Rev. E (in the press).
Sander, L. M. Nature 322, 789–795 (1986).
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Ben-Jacob, E., Schochet, O., Tenenbaum, A. et al. Generic modelling of cooperative growth patterns in bacterial colonies. Nature 368, 46–49 (1994). https://doi.org/10.1038/368046a0
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DOI: https://doi.org/10.1038/368046a0
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