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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

Nature volume 367, pages 40–46 (1994)Cite this article

Abstract

A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.

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Authors and Affiliations

  1. Glaxo-IMCB Group, Institute of Molecular & Cell Biology, National University of Singapore, Kent Ridge, 0511, Singapore

    Edward Manser, Thomas Leung, Harfizah Salihuddin, Zhuo-shen Zhao & Louis Lim

  2. Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK

    Louis Lim

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  1. Edward Manser
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  2. Thomas Leung
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  4. Zhuo-shen Zhao
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  5. Louis Lim
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Manser, E., Leung, T., Salihuddin, H. et al. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40–46 (1994). https://doi.org/10.1038/367040a0

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