Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb


VARIOUS functions of glutamate transmission are mediated by both ionotropic and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs) consist of at least six different subtypes that are classified into three subgroups, mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological roles are largely unknown. Here we report the identification of a very potent agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in granule cell dendrites that form dendrodendritic synapses with mitral cells in the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination with slice patch-recording, we demonstrate that the granule cell mGluR2 presynaptically suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell. Our results indicate that mGluR2 in granule cells plays an important role in the persistent excitation of olfactory sensory transmission in the accessory olfactory bulb by relieving mitral cells from the GABA inhibition.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Nakanishi, S. Science 258, 597–603 (1992).

    ADS  CAS  Article  Google Scholar 

  2. Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R. & Nakanishi, S. Nature 349, 760–765 (1991).

    ADS  CAS  Article  Google Scholar 

  3. Houamed, K. M. et al. Science 252, 1318–1321 (1991).

    ADS  CAS  Article  Google Scholar 

  4. Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R. & Nakanishi, S. Neuron 8, 169–179 (1992).

    CAS  Article  Google Scholar 

  5. Abe, T. et al. J. biol. Chem. 267, 13361–13368 (1992).

    CAS  PubMed  Google Scholar 

  6. Hayashi, Y. et al. Br. J. Phamac. 107, 539–543 (1992).

    CAS  Article  Google Scholar 

  7. Ohfune, Y., Shimamoto, K., Ishida, M. & Shinozaki, H. Bioorg. med. Chem. Lett. 3, 15–18 (1993).

    CAS  Article  Google Scholar 

  8. Ishida, M., Saitoh, T., Shimamoto, K., Ohfune, Y. & Shinozaki, H. Br. J. Pharmac. 109, 1169–1177 (1993).

    CAS  Article  Google Scholar 

  9. Ohishi, H., Shigemoto, R., Nakanishi, S. & Mizuno, N. Neuroscience 53, 1009–1018 (1993).

    CAS  Article  Google Scholar 

  10. Ohishi, H., Shigemoto, R., Nakanishi, S. & Mizuno, N. J. comp. Neurol. 335, 252–266 (1993).

    CAS  Article  Google Scholar 

  11. Rall, W. & Shepherd, G. M. J. Neurophysiol. 31, 884–915 (1968).

    CAS  Article  Google Scholar 

  12. Mori, K. Prog. Neurobiol. 29, 275–320 (1987).

    CAS  Article  Google Scholar 

  13. Shepherd, G. M. Sci. Am. 238, 92–103 (1978).

    Article  Google Scholar 

  14. Edwards, F. A., Konnerth, A., Sakmann, B. & Takahashi, T. Pflügers Arch. 414, 600–612 (1989).

    CAS  Article  Google Scholar 

  15. Takahashi, T. J. Physiol., Lond. 450, 593–611 (1992).

    CAS  Article  Google Scholar 

  16. Moriyoshi, K. et al. Nature 354, 31–37 (1991).

    ADS  CAS  Article  Google Scholar 

  17. Kawai, M., Horikawa, Y., Ishihara, T., Shimamoto, K. & Ohfune, Y. Eur. J. Pharmac. 211, 195–202 (1992)

    CAS  Article  Google Scholar 

  18. Shigemoto, R. et al. Neurosci. Lett. 153, 157–160 (1993).

    CAS  Article  Google Scholar 

  19. Van der Kloot, W. Prog. Neurobiol. 36, 93–130 (1991).

    CAS  Article  Google Scholar 

  20. Ito, S. & Cherubini, E. J. Physiol., Lond. 440, 67–83 (1991).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hayashi, Y., Momiyama, A., Takahashi, T. et al. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature 366, 687–690 (1993).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing