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Human basophil degranulation is not triggered by very dilute antiserum against human IgE

Nature volume 366, pages 525–527 (1993)Cite this article

Abstract

We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (102–10120) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following as closely as possible the methods of the original study, we can find no evidence for any periodic or polynomial change of degranulation as a function of anti-lgE dilution. Our results contain a source of variation for which we cannot account, but no aspect of the data is consistent with the previously published claims.

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References

  1. Davenas, E. et al. Nature 333, 816–818 (1988).

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Authors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK

    S. J. Hirst, N. A. Hayes & J. C. Foreman

  2. Department ofStatistical Science, University College London, Gower Street, London, WC1E 6BT, UK

    J. Burridge

  3. Department of Chemistry, University College London, Gower Street, London, WC1E 6BT, UK

    F. L. Pearce

Authors
  1. S. J. Hirst
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  2. N. A. Hayes
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  3. J. Burridge
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  4. F. L. Pearce
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  5. J. C. Foreman
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Hirst, S., Hayes, N., Burridge, J. et al. Human basophil degranulation is not triggered by very dilute antiserum against human IgE. Nature 366, 525–527 (1993). https://doi.org/10.1038/366525a0

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  • DOI: https://doi.org/10.1038/366525a0

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