Parallel genome analysis by two-dimensional DNA typing

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By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

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Mullaart, E., de Vos, G., te Meerman, G. et al. Parallel genome analysis by two-dimensional DNA typing. Nature 365, 469–471 (1993) doi:10.1038/365469a0

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