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Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

Abstract

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.

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References

  1. Olson, E. N. Genes Dev. 4, 1454–1461 (1990).

    CAS  Article  Google Scholar 

  2. Weintraub, H. et al. Science 251, 761–766 (1991).

    ADS  CAS  Article  Google Scholar 

  3. Buckingham, M. Trends Genet. 8, 144–148 (1992).

    CAS  Article  Google Scholar 

  4. Wright, W. E. Curr. Opin. genet. Dev. 2, 243–248 (1992).

    CAS  Article  Google Scholar 

  5. Braun, T., Rudnicki, M. A., Arnold, H.-H. & Jaenisch, R. Cell 71, 369–382 (1992).

    CAS  Article  Google Scholar 

  6. Rudnicki, M. A., Braun, T., Hinuma, S. & Jaenisch, R. Cell 71, 383–390 (1992).

    CAS  Article  Google Scholar 

  7. Ott, M.-O., Bober, E., Lyons, G., Arnold, H.-H. & Buckingham, M. Development 111, 1097–1107 (1991).

    CAS  PubMed  Google Scholar 

  8. Wright, W. E., Sassoon, D. A. & Lin, V. K. Cell 56, 607–617 (1989).

    CAS  Article  Google Scholar 

  9. Sassoon, D. et al. Nature 341, 303–307 (1989).

    ADS  CAS  Article  Google Scholar 

  10. Hinterberger, T. J., Sassoon, D. A., Rhodes, S. J. & Konieczny, S. F. Devl Biol. 147, 144–156 (1991).

    CAS  Article  Google Scholar 

  11. Bober, E. et al. J. Cell Biol. 113, 1255–1265 (1991).

    CAS  Article  Google Scholar 

  12. Edmondson, D. G. & Olson, E. N. Genes Dev. 3, 628–640 (1989).

    CAS  Article  Google Scholar 

  13. Brunetti, A. & Goldfine, I. D. Molec. Endocr. 4, 880–885 (1990).

    CAS  Article  Google Scholar 

  14. Florini, J. R. & Ewton, D. Z. J. biol. Chem. 265, 13435–13437 (1990).

    CAS  PubMed  Google Scholar 

  15. Olson, E. N. et al. Genomics 8, 427–434 (1990).

    CAS  Article  Google Scholar 

  16. Edmondson, D. G., Cheng, T. C., Cserjesi, P., Chakraborty, T. & Olson, E. N. Molec. cell. Biol. 12, 3665–3677 (1992).

    CAS  Article  Google Scholar 

  17. Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 338, 348–352 (1988).

    ADS  Article  Google Scholar 

  18. McMahon, A. P. & Bradley, A. Cell 62, 1073–1085 (1990).

    CAS  Article  Google Scholar 

  19. Wright, W. E., Binder, M. & Funk, W. Molec. cell. Biol. 11, 4104–4110 (1991).

    CAS  Article  Google Scholar 

  20. Chen, J. M. J. Anat., London 86, 373–386 (1952).

    CAS  Google Scholar 

  21. Chen, J. M. J. Anat., London 87, 130–149 (1953).

    CAS  Google Scholar 

  22. Chakraborty, T. & Olson, E. N. Molec. cell. Biol. 11, 6103–6108 (1991).

    CAS  Article  Google Scholar 

  23. Cheng, T. C., Hanley, T. A., Mudd, J., Merlie, J. P. & Olson, E. N. J. Cell Biol. 119, 1649–1656 (1992).

    CAS  Article  Google Scholar 

  24. Cheng, T.-C., Wallace, M., Merlie, J. P. & Olson, E. N. Science 261, 215–218 (1993).

    ADS  CAS  Article  Google Scholar 

  25. Schwarz, J. J., Chakraborty, T., Martin, J., Zhou, J. & Olson, E. N. Molec. cell. Biol. 12, 266–275 (1992).

    CAS  Article  Google Scholar 

  26. Ramirez-Solis, R. et al. Analyt. Biochem. 201, 331–335 (1992).

    CAS  Article  Google Scholar 

  27. Li, L. et al. Cell 71, 1181–1194 (1992).

    CAS  Article  Google Scholar 

  28. McLeod, M. J. Teratology 22, 299–301 (1980).

    CAS  Article  Google Scholar 

  29. Chomczynski, P. & Sacchi, N. Analyt. Biochem. 162, 156–159 (1987).

    CAS  Article  Google Scholar 

  30. Buskin, J. N., Jaynes, J. B., Chamberlain, J. S. & Hauschka, S. D. J. molec. Evol. 22, 334–341 (1985).

    ADS  CAS  Article  Google Scholar 

  31. Medford, R. M., Wydon, R. M., Nguyen, H. T. & Nadal-Ginard, B. Proc. natn. Acad. Sci. U.S.A. 77, 5749–5753 (1980).

    ADS  CAS  Article  Google Scholar 

  32. Isenberg, K. E., Mudd, J., Shah, V. & Merlie, J. P. Nucleic Acids Res. 14, 5111 (1986).

    CAS  Article  Google Scholar 

  33. Yu, L., LaPolla, R. J. & Davidson, N. Nucleic Acids Res. 14, 3539–3555 (1986).

    CAS  Article  Google Scholar 

  34. LaPolla, R. D., Mayne, K. M. & Davidson, N. Proc. natn. Acad. Sci. U.S.A. 81, 7970–7974 (1984).

    ADS  CAS  Article  Google Scholar 

  35. Davis, R. L., Weintraub, H. & Lassar, A. Cell 51, 987–1000 (1987).

    CAS  Article  Google Scholar 

  36. Rhodes, S. J. & Konieczny, S. F. Genes Dev. 3, 2050–2061 (1991).

    Article  Google Scholar 

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Hasty, P., Bradley, A., Morris, J. et al. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature 364, 501–506 (1993). https://doi.org/10.1038/364501a0

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