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Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

Nature volume 362, pages 722728 (22 April 1993) | Download Citation

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Abstract

Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region–leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.

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References

  1. 1.

    Cell 63, 665–672 (1990).

  2. 2.

    , , & Proc. natn. Acad. Sci. U.S.A. 82, 6384–6388 (1985).

  3. 3.

    , , & Cell 51, 975–985 (1987).

  4. 4.

    et al. Genes Dev. 4, 1588–1601 (1990).

  5. 5.

    et al. Nature 283, 637–642 (1980).

  6. 6.

    et al. Blood 76, 221–227 (1990).

  7. 7.

    , , , & Genes Dev. 4, 380–389 (1990).

  8. 8.

    et al. Nature 344, 309–313 (1990).

  9. 9.

    & Cell 55, 17–26 (1988).

  10. 10.

    et al. Genes Dev. 5, 1387–1394 (1991).

  11. 11.

    , , & EMBO 9, 2159–2167 (1990).

  12. 12.

    , , & EMBO 9, 2169–2178 (1990).

  13. 13.

    & EMBO J. 10, 1391–1398 (1991).

  14. 14.

    , , & Molec. cell. Biol. 12, 2135–2142 (1992).

  15. 15.

    & Proc. natn. Acad. Sci. U.S.A. 89, 5809–5813 (1992).

  16. 16.

    & Proc. natn. Acad. Sci. U.S.A. 88, 10188–10192 (1991).

  17. 17.

    & Proc. natn. Acad. Sci. U.S.A. 88, 8676–8680 (1991).

  18. 18.

    et al. Molec. cell Biol. 11, 4679–4689 (1991).

  19. 19.

    , , & Proc. natn. Acad. Sci. U.S.A. 86, 2554–2558 (1989).

  20. 20.

    , , & Genes Dev. 4, 993–1006 (1990).

  21. 21.

    , & Nucleic Acids Res. 20, 237–243 (1992).

  22. 22.

    & Blood 77, 2272–2284 (1991).

  23. 23.

    & Cell 58, 877–885 (1989).

  24. 24.

    et al. Nature 339, 446–451 (1989).

  25. 25.

    , , , & Nucleic Acids Res. 17, 37–54 (1989).

  26. 26.

    , , & Nucleic Acids Res. 18, 6011–6017 (1990).

  27. 27.

    et al. Nature 344, 447–449 (1990).

  28. 28.

    , , & Proc. natn. Acad. Sci. U.S.A. 86, 6548–6551 (1989).

  29. 29.

    , , , & Eur. J. Biochem. 205, 217–222 (1992).

  30. 30.

    , , & Mech. Dev. 34, 3–10 (1991).

  31. 31.

    , & Cell 68, 1061–1075 (1992).

  32. 32.

    et al. Nature 362, 768–770 (1993).

  33. 33.

    , & Science 240, 1759–1764 (1988).

  34. 34.

    et al. Science 238, 1386–1392 (1987).

  35. 35.

    & Molec. cell. Biol. 8, 2063–2069 (1988).

  36. 36.

    , , & Genes Dev. 3, 2083–2090 (1989).

  37. 37.

    Proc. natn. Acad. Sci. U.S.A. 81, 6442–6446 (1984).

  38. 38.

    , , , & Science 242, 1430–1433 (1988).

  39. 39.

    , , , & Proc. natn. Acad. Sci. U.S.A. 80, 3183–3187 (1983).

  40. 40.

    , , & Nature 344, 444–446 (1990).

  41. 41.

    , & Molec. cell. Biol. 7, 1751–1758 (1987).

  42. 42.

    , , & EMBO J. 10, 1891–1902 (1991).

  43. 43.

    , & Proc. natn. Acad. Sci. U.S.A. 84, 7149–7153 (1987).

  44. 44.

    & J. biol. Chem. 267, 15642–15649 (1992).

  45. 45.

    et al. Nature Genet. 1, 92–98 (1992).

  46. 46.

    & Eur. J. Biochem. 135, 321–330 (1983).

  47. 47.

    , , & Meth. Enzym. 101, 587–597 (1983).

  48. 48.

    Meth. Enzym. 208, 10–23 (1991).

  49. 49.

    , & Molecular Cloning: A Laboratory Manual 2nd edn (Cold Spring Harbor Laboratory Press, New York, 1989).

  50. 50.

    , , , & Electrophoresis 11, 537–553 (1990).

  51. 51.

    et al. Cell 62, 1019–1029 (1990).

  52. 52.

    & Analyt. Biochem. 183, 290–300 (1989).

  53. 53.

    , , & in Techniques in Protein Chemistry IV (ed. Hogue-Angeletti, R.) (Academic, San Diego, in the press).

  54. 54.

    , & Proc. natn. Acad. Sci. U.S.A. 85, 1487–1491 (1988).

  55. 55.

    & Science 251, 1211–1217 (1991).

  56. 56.

    & Nucleic Acids Res. 19, 2499 (1991).

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Affiliations

  1. Division of Hematology/Oncology, Children's Hospital, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA

    • Nancy C. Andrews
    • , Mark B. Davidson
    •  & Stuart H. Orkin
  2. Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA

    • Hediye Erdjument-Bromage
    •  & Paul Tempst
  3. Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA

    • Stuart H. Orkin
  4. To whom correspondence should be addressed at the Children's Hospital.

    • Stuart H. Orkin

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https://doi.org/10.1038/362722a0

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