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Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

Nature volume 362, pages 722–728 (1993)Cite this article

Abstract

Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region–leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.

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Author information

Author notes

  1. Stuart H. Orkin: To whom correspondence should be addressed at the Children's Hospital.

Authors and Affiliations

  1. Division of Hematology/Oncology, Children's Hospital, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Nancy C. Andrews, Mark B. Davidson & Stuart H. Orkin

  2. Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Hediye Erdjument-Bromage & Paul Tempst

  3. Howard Hughes Medical Institute, Boston, Massachusetts, 02115, USA

    Stuart H. Orkin

Authors
  1. Nancy C. Andrews
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  2. Hediye Erdjument-Bromage
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  3. Mark B. Davidson
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  4. Paul Tempst
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  5. Stuart H. Orkin
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Andrews, N., Erdjument-Bromage, H., Davidson, M. et al. Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein. Nature 362, 722–728 (1993). https://doi.org/10.1038/362722a0

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