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Infection of natural killer cells by human herpesvirus 6

Nature volume 362, pages 458–462 (1993)Cite this article

Abstract

NATURAL killer (NK) cells are a functionally defined subset of non-T, non-B lymphocytes of bone marrow origin, which induce lysis of selected target cells, including neoplastic and virus-infected cells1–3. The NK cell function provides an important mechanism of primary defence against viruses in vivo, as demonstrated by the occurrence of multiple herpesvirus infections in patients con-genitally lacking NK cells4, 5. Here we show that functionally competent CD3- NK clones can be productively infected by human herpesvirus 6 (HHV-6)6, a T-lymphotropic DNA virus7 that may play a role in the acquired immunodeficiency syndrome (AIDS)8 and in the chronic fatigue syndrome9, two disorders associated with a defective NK cell activity10–15. The infection is cytopathic and induces de novo expression of CD4, an antigen not expressed within the NK lineage16, 17, thereby predisposing NK cells to infection by human immunodeficiency virus type 1 (HIV-1). These results provide evidence that a herpesvirus can directly target and kill NK cells, a potential strategy to suppress the natural anti-viral immunity of the host.

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References

  1. Herberman, R. B. & Ortaldo, J. R. Science 214, 24–27 (1981).

    Article  ADS  CAS  Google Scholar 

  2. Trinchieri, G. Adv. Immun. 47, 187–211 (1989).

    Article  CAS  Google Scholar 

  3. Robertson, M. J. & Ritz, J. Blood 76, 2421–2438 (1991).

    Google Scholar 

  4. Fleisher, G., Koven, N., Kamiya, H. & Henle, W. J. Pediatr. 100, 727–733 (1982).

    Article  CAS  Google Scholar 

  5. Biron, C. A., Byron, K. S. & Sullivan, J. L. N. Engl. J. Med. 320, 1731–1734 (1989).

    Article  CAS  Google Scholar 

  6. Salahuddin, S. Z. et al. Science 234, 596–601 (1986).

    Article  ADS  CAS  Google Scholar 

  7. Lusso, P. et al. J. exp. Med. 167, 1659–1670 (1988).

    Article  CAS  Google Scholar 

  8. Lusso, P., Ablashi, D. V. & Luka, J. in Human Herpesvirus-6 (eds Ablashi, D. V., Krueger, G. R. F. & Salahuddin, S. Z.) 121–133 (Elsevier, Amsterdam, 1992).

    Google Scholar 

  9. Buchwald, D. et al. Ann. Intern. Med. 116, 103–113 (1992).

    Article  CAS  Google Scholar 

  10. Rook, A. H. et al. J. clin. Invest. 72, 398–403 (1983).

    Article  CAS  Google Scholar 

  11. Bonavida, B., Katz, J. D. & Gottlieb, M. J. Immun. 137, 1157–1160 (1986).

    CAS  PubMed  Google Scholar 

  12. Sirianni, M. C., Soddu, S., Malorni, W., Arancia, G. & Aiuti, F. J. Immun. 140, 2565–2568 (1988).

    CAS  PubMed  Google Scholar 

  13. Aoki, T., Usuda, Y., Miyakoshi, H., Tamura, K. & Herberman, R. B. Nat. Immun. Cell Growth Regul. 6, 116–128 (1987).

    CAS  PubMed  Google Scholar 

  14. Caligiuri, M. et al. J. Immun. 139, 3306–3313 (1987).

    CAS  PubMed  Google Scholar 

  15. Klimas, N. G., Salvato, F. R., Morgan, R. & Fletcher, M. A. J. clin. Microbiol. 28, 1403–1410 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Lanier, L. L. & Phillips, J. H. in Leukocyte Typing II Vol. 3 (eds Reinherz, E. L., Haynes, B. F., Nadler, L. M. & Bernstein, I. D.) 157–198 (Springer, New York. 1986).

    Book  Google Scholar 

  17. Ritz, J. et al. Adv. Immun. 42, 181–211 (1988).

    Article  CAS  Google Scholar 

  18. Moretta, A. et al. J. exp. Med. 171, 695–714 (1990).

    Article  CAS  Google Scholar 

  19. Lusso, P. et al. Nature 337, 370–373 (1991).

    Article  ADS  Google Scholar 

  20. Dalgleish, A. G. et al. Nature 312, 763–767 (1984).

    Article  ADS  CAS  Google Scholar 

  21. Ruscetti, F. W. et al. J. Immun. 136, 3619–3624 (1986).

    CAS  PubMed  Google Scholar 

  22. Robinson, W. E. et al. Hum. Pathol. 19, 535–540 (1988).

    Article  Google Scholar 

  23. Chehimi, J. et al. J. Virol. 65, 1812–1822 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Oldstone, M. B. A. J. Virol. 65, 6381–6386 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Lusso, P. et al. J. Immun. 147, 2147–2153 (1991).

    Google Scholar 

  26. Holmes, G. P. et al. Ann. intern. Med. 108, 387–391 (1988).

    Article  CAS  Google Scholar 

  27. Moretta, A., Pantaleo, G., Moretta, L., Cerottini, J. C. & Mingari, M. C. J. exp. Med. 157, 743–751 (1983).

    Article  CAS  Google Scholar 

  28. Balachandran, N., Amelse, R. E., Zhou, W. W. & Chang, C. K. J. Virol. 63, 2835–2840 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Chomczynski, P. & Sacchi, M. Analyt. Biochem. 162, 156–159 (1987).

    Article  CAS  Google Scholar 

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Author notes

  1. Paolo Lusso: To whom correspondence should be addressed.

Authors and Affiliations

  1. Laboratory of Tumor Cell Biology, National Cancer Institute Bethesda, Maryland, 20892, USA

    Paolo Lusso, Alfredo Garzino-Demo, Richard W. Crowley & Robert C. Gallo

  2. Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Mauro S. Malnati & Eric O. Long

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  1. Paolo Lusso
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  2. Mauro S. Malnati
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  6. Robert C. Gallo
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Lusso, P., Malnati, M., Garzino-Demo, A. et al. Infection of natural killer cells by human herpesvirus 6. Nature 362, 458–462 (1993). https://doi.org/10.1038/362458a0

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