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Inositol trisphosphate and calcium signalling

Nature volume 361, pages 315325 (28 January 1993) | Download Citation

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Abstract

Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.

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Affiliations

  1. Michael J. Berridge is at the AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB23EJ, UK.

    • Michael J. Berridge

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https://doi.org/10.1038/361315a0

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