Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

Abstract

LANGERHANS cells (LC) are the principal accessory cells present in epidermis1. Because LC have limited capacity for self-renewal2, epidermis is continually repopulated by as-yet uncharacterized bone marrow-derived LC progenitors3,4. In addition, although LC persist in epidermis for extended periods, LC are induced to migrate from skin to regional lymph nodes after antigen exposure5. To begin to elucidate mechanisms involved in LC trafficking, we characterized LC-keratinocyte (KC) interactions. Here we report that fresh murine LC express cadherins, and that LC adhere to KC in vitro through E-cadherin. Cultured LC (which may bear a phenotypic and functional relationship to LC that have migrated to lymph nodes6,7) express lower levels of E-cadherin and exhibit

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Stingl, G., Katz, S. I., Clement, L., Green, I. & Shevach, E. M. J. Immun. 121, 2005–2013 (1978).

    CAS  PubMed  Google Scholar 

  2. Breathnach, S. M. Epidermal Langerhans Cells (ed. Schuler, G.) 23–47 (CRC, Boca Raton, 1991).

    Google Scholar 

  3. Katz, S. I., Tamaki, K. & Sachs, D. H. Nature 282, 324–326 (1979).

    Article  ADS  CAS  Google Scholar 

  4. Frelinger, J. G., Hood, L., Hill, S. & Frelinger, J. A. Nature 282, 321–323 (1979).

    Article  ADS  CAS  Google Scholar 

  5. Kripke, M. L. Dunn, C. G., Jeevan, A., Tang, J. & Bucana, C. J. Immun. 145, 2833–2838 (1990).

    CAS  PubMed  Google Scholar 

  6. Schuler, G. & Steinman,x R. M. J. exp. Med. 161, 526–546 (1985).

    Article  CAS  Google Scholar 

  7. Romani, N. et al. J. invest. Dermal. 93, 600–609 (1989).

    Article  CAS  Google Scholar 

  8. Nose, A. & Takeichi, M. J. Cell Biol. 103, 2649–2658 (1986).

    Article  CAS  Google Scholar 

  9. Goodwin, L. et al. Biochim. biophys Acta 173, 1224–1230 (1990).

    CAS  Google Scholar 

  10. Koch, P. J. et al. Eur. J. Cell Biol. 53, 1–12 (1990).

    CAS  PubMed  Google Scholar 

  11. Collins, J. E. et al. J. Cell Biol. 113, 381–391 (1991).

    Article  CAS  Google Scholar 

  12. Mechanic, S., Raynor, K., Hill, J. E. & Cowin, P. Proc. natn. Acad. Sci. U.S.A. 88, 4476–4480 (1991).

    Article  ADS  CAS  Google Scholar 

  13. Amagai, M., Klaus-Kovtun, V. & Stanley, J. R. Cell 67, 869–877 (1991).

    Article  CAS  Google Scholar 

  14. Shirayoshi, Y., Nose, A., Iwasaki, K. & Takeichi, M. Cell Struct. Funct. 11, 245–252 (1986).

    Article  CAS  Google Scholar 

  15. Nose, A., Nagafuchi, A. & Takeichi, M. Cell 54, 993–1001 (1988).

    Article  CAS  Google Scholar 

  16. Takeichi, M. A. Rev. Biochem. 59, 237–252 (1990).

    Article  CAS  Google Scholar 

  17. Takeichi, M. Science 251, 1451–1455 (1991).

    Article  ADS  CAS  Google Scholar 

  18. Yoshida-Noro, C. Suzuki, N. & Takeichi, M. Devl Biol. 101, 19–27 (1984).

    Article  CAS  Google Scholar 

  19. Donalies, M., Cramer, M., Ringwald, M. & Starzinski-Powitz, A. Proc. natn. Acad. Sci. U.S.A. 88, 8024–8028 (1991).

    Article  ADS  CAS  Google Scholar 

  20. Hauser, C. Snapper, C. M., Ohara, J., Paul, W. E. & Katz, S. I. Eur. J. Immun. 19, 245–251 (1989).

    Article  CAS  Google Scholar 

  21. Tang, A. & Udey, M. C. J. Immun. 146, 3347–3355 (1991).

    CAS  PubMed  Google Scholar 

  22. Rasanen, L. Lehto, M., Reunala, T. & Leinikki, P. J. invest. Dermat. 86, 9–12 (1986).

    Article  CAS  Google Scholar 

  23. Witsell, A. B. & Schook, L. B. Biotechniques 9, 318–322 (1990).

    CAS  PubMed  Google Scholar 

  24. Nagafuchi, A., Shirayoshi, Y., Okazaki, K., Yasuda, K. & Takeichi, M. Nature 329, 341–343 (1987).

    Article  ADS  CAS  Google Scholar 

  25. Nose, A., Tsuji, K. & Takeichi, M. Cell 61, 147–155 (1990).

    Article  CAS  Google Scholar 

  26. Ringwald, M., Baribault, H., Schmidt, C. & Kemler, R. Nucleic Acid Res. 19, 6533–6539 (1991).

    Article  CAS  Google Scholar 

  27. Yuspa, S. H. in Methods in Skin Research (eds Skerrow, D. & Skerrow, C. J.) 213–249 (Wiley, Chichester, 1985).

    Google Scholar 

  28. Hennings, H. et al. Cell 19, 245–254 (1980).

    Article  CAS  Google Scholar 

  29. Tang, A. & Udey, M. C. Eur. J. Immun. 22, 581–586 (1992).

    Article  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tang, A., Amagai, M., Granger, L. et al. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361, 82–85 (1993). https://doi.org/10.1038/361082a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/361082a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing