Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular analysis of the association of HLA-B53 and resistance to severe malaria

Nature volume 360, pages 434–439 (1992)Cite this article

Abstract

The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. Amiel, J. L. in Histocompatibllity Testing 1967 79–83 (Munksgaard, Copenhagen, 1967).

    Google Scholar 

  2. Tiwari, J. L. & Terasaki, P. I. (eds) HLA and Disease Associations (Springer, New York, 1985).

  3. Falk, K., Rotzscke, O., Stevanovic, S., Jung, G. & Rammensee, H. Nature 351, 290–296 (1991).

    ADS  CAS  Article  Google Scholar 

  4. Jardetsky, T. S., Lane, W. S., Robinson, R. A., Madden, D. R. & Wiley, D. C. Nature 353, 326–329 (1991).

    ADS  Article  Google Scholar 

  5. Hill, A. V. S. et al. Nature 352, 595–600 (1991).

    ADS  CAS  Article  Google Scholar 

  6. Perlmann, P. & Miller, L. (eds) Immun. Lett. 25, 1–294 (1990).

  7. Nussenzweig, R. S., Vanderberg, J., Most, H. & Orton, C. Nature 222, 488–489 (1969).

    ADS  CAS  Article  Google Scholar 

  8. Clyde, D. F., McCarthy, V. C., Miller, R. M. & Hormick, R. B. Am. J. med Sci. 266, 398–403 (1973).

    CAS  Article  Google Scholar 

  9. Schofield, L. et al. Nature 330, 664–666 (1987).

    ADS  CAS  Article  Google Scholar 

  10. Weiss, W. R., Sedegah, M., Beaudoin, R. L., Miller, L. H. & Good, M. F. Proc. natn. Acad. Sci. U.S.A. 85, 573–576 (1988).

    ADS  CAS  Article  Google Scholar 

  11. Kumar, S. et al. Nature 334, 258–260 (1988).

    ADS  CAS  Article  Google Scholar 

  12. Romero, P., Maryanski, J. L., Corradin, G., Nussenzweig, R. S. & Nussenzweig V. Nature 341, 323–326 (1989).

    ADS  CAS  Article  Google Scholar 

  13. Hoffman, S. L. et al. Science 244, 1078–1081 (1989).

    ADS  CAS  Article  Google Scholar 

  14. Malik, A., Egan, J. E., Houghten, R. A., Sadoff, J. C. & Hoffmann, S. L. Proc. natn. Acad. Sci. U.S.A. 88, 3300–3304 (1991).

    ADS  CAS  Article  Google Scholar 

  15. Doolan, D. L., Houghten, R. A. & Good, M. F. Int. Immun. 3, 511–516 (1991).

    CAS  Article  Google Scholar 

  16. Sedegah, M. et al. J. Immun. 149, 966–971 (1992).

    CAS  PubMed  Google Scholar 

  17. Weiss, W. R. et al. J. exp. Med. 171, 1083–1090 (1990).

    Article  Google Scholar 

  18. Rodrigues, M. M. et al. Int. Immun. 3, 579–585 (1991).

    CAS  Article  Google Scholar 

  19. Khusmith, S. et al. Science 252, 715–718 (1991).

    ADS  CAS  Article  Google Scholar 

  20. Dame, J. B. et al. Science 225, 593–599 (1984).

    ADS  CAS  Article  Google Scholar 

  21. Robson, K. J. H. et al. Nature 335, 79–82 (1988).

    ADS  CAS  Article  Google Scholar 

  22. Cowan, G., Krishna, S., Crisanti, A. & Robson, K. J. H. Lancet 339, 1412–1413 (1992).

    CAS  Article  Google Scholar 

  23. Moelans, I. I. M. D., Meis, J. F. G. M., Kocken, C., Konings, R. N. H. & Schoenmakers, J. G. G. Molec. Biochem. Parasitol. 45, 193–204 (1991).

    CAS  Article  Google Scholar 

  24. Guerin-Marchand, C. et al. Nature 329, 164–167 (1987).

    ADS  CAS  Article  Google Scholar 

  25. Zhu, J. & Hollingdale, M. Molec. Biochem. Parasitol. 48, 223–226 (1991).

    CAS  Article  Google Scholar 

  26. Elvin, J., Cerundolo, V., Elliot, T. & Townsend, A. Eur. J. Immun. 21, 2025–2031 (1991).

    CAS  Article  Google Scholar 

  27. Madden, D. R., Gorga, J. C., Strominger, J. L. & Wiley, D. C. Nature 353, 321–325 (1991).

    ADS  CAS  Article  Google Scholar 

  28. Harris, R. & Zervas, J. D. Nature 221, 1062–1063 (1969).

    ADS  CAS  Article  Google Scholar 

  29. Druihle, P. & Marchand, C. in New Strategies in Parasitology (ed. McAdam, K. P. W. J.) (Churchill-Livingstone, Edinburgh, 1989).

    Google Scholar 

  30. Mellouk, S., Lunel, F., Sedegah, M., Beaudoin, R.-L. & Druihle, P. Lancet 335, 721 (1990).

    CAS  Article  Google Scholar 

  31. Suhrbier, A., Winger, L. A., Castellano, E. & Sinden, R. E. Infect. Immun. 58, 2834–2839 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. McGregor, I. A. & Wilson, R. J. M. in Malaria: Principles and Practice of Malariology 559–620 (Churchill-Livingstone, Edinburgh, 1988).

    Google Scholar 

  33. Meis, J. F. G. M. et al. Cell Tiss. Res. 244, 345–350 (1986).

    CAS  Article  Google Scholar 

  34. Suhrbier, A. Parasitol. Today 7, 160–163 (1991).

    CAS  Article  Google Scholar 

  35. Van Bleek, G. M. & Nathenson S. G. Nature 348, 213–216 (1990).

    ADS  CAS  Article  Google Scholar 

  36. Jacobsen, S., Shida, H., McFarlin, D. E., Fauci, A. S. & Koenig, S. Nature 348, 245–248 (1990).

    ADS  Article  Google Scholar 

  37. Nixon, D. F., Broliden, K., Ogg, G. & Broliden, P. A. Immunology 76, 515–534 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Hollingdale, M. R. et al. Immun. Lett. 25, 71–81 (1990).

    CAS  Article  Google Scholar 

  39. Carreno, B. M., Turner, R. V., Biddison, W. E. & Coligan, J. E. J. Immun. 148, 894–899 (1992).

    CAS  PubMed  Google Scholar 

  40. Rosenberg, R., Wirtz, R. A., Schneider, I. & Burge, R. Trans. R. Soc. trop. Med. Hyg. 84, 209–212 (1990).

    CAS  Article  Google Scholar 

  41. Pamer, E. G., Harty, J. T. & Bevan, M. J. Nature 353, 852–855 (1991).

    ADS  CAS  Article  Google Scholar 

  42. Harty, J. T. & Bevan, M. J. J. exp. Med. 175, 1531–1538 (1992).

    CAS  Article  Google Scholar 

  43. De la Cruz, V. F., Lal, A. A. & McCutchan, T. F. J. biol. Chem. 262, 11935–11939 (1987).

    CAS  PubMed  Google Scholar 

  44. Good, M. F., Kumar, S. & Miller, L. H. Immun. Today 9, 351–355 (1988).

    CAS  Article  Google Scholar 

  45. Lockyer, M. J., Marsh, K. & Newbold, C. I. Molec. Biochem. Parasitol. 37, 275–280 (1989).

    CAS  Article  Google Scholar 

  46. Arnot, D. Parasitol. Today 5, 138–142 (1989).

    CAS  Article  Google Scholar 

  47. Good, M. F. et al. Proc. natn. Acad. Sci. U.S.A. 85, 1199–1203 (1988).

    ADS  CAS  Article  Google Scholar 

  48. Lockyer, M. Parasitol. Today 6, 76 (1990).

    CAS  Article  Google Scholar 

  49. Yoshida, N. et al. Expl Parasitol. 71, 386–392 (1990).

    CAS  Article  Google Scholar 

  50. Doolan, D. L., Saul, A. J. & Good, M. F. Infect. Immun. 60, 765–682 (1991).

    Google Scholar 

  51. McCutchan, T. F. & Waters, A. P. Immun. Lett. 25, 23–26 (1990).

    CAS  Article  Google Scholar 

  52. Allsopp, C. E. M. et al. Hum. Immun. 30, 105–109 (1991).

    CAS  Article  Google Scholar 

  53. Hayashi, H. et al. Immunogenetics 32, 195–199 (1990).

    CAS  Article  Google Scholar 

  54. Sutton, J. et al. Eur. J. Immun. (in the press).

  55. Yamamoto, J., Kariyone, A., Akiyama, N., Kano, K. & Takiguchi, M. Proc. natn. Acad. Sci. U.S.A. 87, 2583–2587 (1990).

    ADS  CAS  Article  Google Scholar 

  56. Barnstable, C. J. et al. Cell 14, 9–20 (1978).

    CAS  Article  Google Scholar 

  57. Doolan, D. L., Saul, A. J. & Good, M. F. Infect. Immun. 60, 675–682 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Townsend, A. et al. Cell 62, 285–295 (1990).

    CAS  Article  Google Scholar 

  59. Schumacher, T. N. M. et al. Cell 62, 563–567 (1990).

    CAS  Article  Google Scholar 

  60. Cerundolo, V. Nature 345, 449–456 (1990).

    ADS  CAS  Article  Google Scholar 

  61. Elvin, J. et al. J. Immun. Meth. (in the press).

  62. Ellis, S. et al. Hum. Immun. 13, 13–20 (1985).

    CAS  Article  Google Scholar 

  63. Bodmer, H. C., Gotch, F. M. & McMichael, A. J. Nature 337, 653–655 (1989).

    ADS  CAS  Article  Google Scholar 

  64. Conway, D., Greenwood, B. M. & McBride, J. S. Parasitology 103, 1–6 (1991).

    Article  Google Scholar 

  65. Pircher, H. P. et al. Nature 346, 629–633 (1990).

    ADS  CAS  Article  Google Scholar 

  66. Phillips, R. E. et al. Nature 354, 453–459 (1991).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, 0X3 9DU, UK

    Adrian V. S. Hill, John Elvin, Catherine E. M. Allsopp, Frances M. Gotch, X. Ming Gao, Alain R. M. Townsend & Andrew J. McMichael

  2. MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, 0X1 3QU, UK

    Anthony C. Willis

  3. Medical Research Council Laboratories, Fajara, Banjul, The Gambia, West Africa

    Michael Aidoo, Brian M. Greenwood & Hilton C. Whittle

  4. Institute of Medical Sciences, University of Tokyo, Minato-ku, Tokyo, 108, Japan

    Masafumi Takiguchis

Authors
  1. Adrian V. S. Hill
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John Elvin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anthony C. Willis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael Aidoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Catherine E. M. Allsopp
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Frances M. Gotch
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. X. Ming Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masafumi Takiguchis
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Brian M. Greenwood
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Alain R. M. Townsend
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Andrew J. McMichael
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Hilton C. Whittle
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hill, A., Elvin, J., Willis, A. et al. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360, 434–439 (1992). https://doi.org/10.1038/360434a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/360434a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing