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Cooperative interaction between c-myc and bcl-2 proto-oncogenes

Nature volume 359, pages 554–556 (1992)Cite this article

Abstract

THE bcl-2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and synergizes with the c-myc oncogene in tumour progression1. The mechanism of synergy is unclear but bcl-2 expression inhibits apoptosis2–6, a property presumably pertinent to its proto-oncogenic mode of action4. We have shown that the c-myc gene is a potent inducer of apoptosis, in addition to its established role in mitogenesis7. Here we show that expression of the bcl-2 protein, Bcl-2, specifically abrogates c-mvoinduced apoptosis without affecting the c-myc mitogenic function. This provides a novel mechanism for oncogene cooperation, of potential importance both in carcinogenesis and in the evolution of drug resistance in tumours.

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Authors and Affiliations

  1. Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK

    Abdallah Fanidi, Elizabeth A. Harrington & Gerard I. Evan

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  1. Abdallah Fanidi
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  2. Elizabeth A. Harrington
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  3. Gerard I. Evan
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Fanidi, A., Harrington, E. & Evan, G. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359, 554–556 (1992). https://doi.org/10.1038/359554a0

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