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Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials

Nature volume 359, pages 531–533 (1992)Cite this article

Abstract

IN mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome1,2. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man3–5 and mouse6,7. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ubely homologues8, are the first genes to be identified on the marsupial Y chromosome.

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References

  1. Jost, A., Vigier, B., Prepin, J. & Perchellet, J. Rec. Prog. Horm. Res. 29, 1–41 (1973).

    CAS  PubMed  Google Scholar 

  2. Ford, C. E., Miller, O. J., Polani, P. E., de Almeida, J. C. & Briggs, J. H. Lancet i, 711 (1959).

    Article  Google Scholar 

  3. Sinclair, A. H. et al. Nature 346, 240–244 (1990).

    Article  ADS  CAS  Google Scholar 

  4. Berta, P. et al. Nature 348, 448–450 (1990).

    Article  ADS  CAS  Google Scholar 

  5. Jager, R. J., Anvret, M., Hall, K. & Scherer, G. Nature 348, 452–454 (1991).

    Article  ADS  Google Scholar 

  6. Gubbay, J. et al. Nature 346, 245–250 (1990).

    Article  ADS  CAS  Google Scholar 

  7. Koopman, P., Gubbay, J., Vivian, N., Goodfellow, P. N. & Lovell-Badge, R. Nature 351, 117–121 (1991).

    Article  ADS  CAS  Google Scholar 

  8. Mitchell, M. J., Woods, D. R., Wilcox, S. A., Marshall-Grove, J. A. & Bishop, C. E. Nature (this issue).

  9. Hope, R. M. et al. Aust. J. Zool. 37, 289–313 (1990).

    Article  CAS  Google Scholar 

  10. O Wai-Sum, Short, R. V., Renfree, M. B. & Shaw, G. Nature 331, 716–717 (1988).

    Article  ADS  Google Scholar 

  11. Sharman, G. B. et al Aust. J. Zool. 37, 451–466 (1990).

    Article  Google Scholar 

  12. Page, D. C. et al. Cell 51, 1091–1104 (1987).

    Article  CAS  Google Scholar 

  13. Sinclair, A. H. et al. Nature 336, 780–783 (1988).

    Article  ADS  CAS  Google Scholar 

  14. Nasrin, N. et al. Nature 354, 317–330 (1991).

    Article  ADS  CAS  Google Scholar 

  15. Denny, P., Swift, S. & Ashworth, A. Nucleic Acids Res. 20, 2887 (1992).

    Article  CAS  Google Scholar 

  16. Griffiths, R. Proc. R. Soc. Lond. B 244, 123–128 (1991).

    Article  ADS  CAS  Google Scholar 

  17. Harley, V. et al. Science 255, 453–456 (1992).

    Article  ADS  CAS  Google Scholar 

  18. Hawkins, J. R. et al. Hum. Genet. 88, 471–474 (1992).

    Article  CAS  Google Scholar 

  19. Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning: A Laboratory Manual 2nd edn (Cold Spring Harbor Laboratory Press, New York, 1989).

    Google Scholar 

  20. Sanger, F. et al. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

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Author notes

  1. Jamie W. Foster & Peter N. Goodfellow

    Present address: Department of Genetics, Cambridge University, Tennis Court Road, Cambridge, CB2 3EH, UK

  2. Andrew H. Sinclair

    Present address: Department of Genetics, School of Biological Sciences, University of Sydney, NSW 2006, Australia

Authors and Affiliations

  1. Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, 3083, Australia

    Jamie W. Foster, Francine E. Brennan, Gregory K. Hampikian & Jennifer A. Marshall Graves

  2. Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

    Jamie W. Foster, Peter N. Goodfellow & Andrew H. Sinclair

  3. Laboratory of Eukaryotic Molecular Genetics, Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Robin Lovell-Badge

  4. Department of Zoology, La Trobe University, Bundoora, Victoria, 3083, Australia

    Lynne Selwood

  5. Department of Zoology, University of Melbourne, Parkville, Victoria, 3052, Australia

    Marilyn B. Renfree

  6. School of Biological Sciences, Macquarie University, North Ryde, New South Wales, 2109, Australia

    Desmond W. Cooper

Authors
  1. Jamie W. Foster
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  10. Jennifer A. Marshall Graves
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Foster, J., Brennan, F., Hampikian, G. et al. Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials. Nature 359, 531–533 (1992). https://doi.org/10.1038/359531a0

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