Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

Abstract

Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.

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References

  1. 1

    Bjorkman, P. J. et al. Nature 329, 507–512 (1987).

  2. 2

    Van Bleek, G. M. & Nathenson, S. G. Nature 348, 213–216 (1990).

  3. 3

    Madden, D. R., Gorga, J. C. Strominger, J. L. & Wiley, D. C. Nature 353, 321–325 (1991).

  4. 4

    Jardetzky, T. S. et al. Nature 353, 326–329 (1991).

  5. 5

    Falk, K. et al. Nature 351, 290–296 (1991).

  6. 6

    Townsend, A. R. M. et al. Cell 39, 13–25 (1984).

  7. 7

    Townsend, A. & Bodmer, H. A. Rev. Immun. 7, 601–624 (1989).

  8. 8

    Townsend, A. et al. Nature 340, 443–448 (1989).

  9. 9

    Townsend, A. et al. Cell 62, 285–295 (1990).

  10. 10

    Elliott, T., Cerundolo, V., Elvin, J. & Townsend, A. Nature 351, 402–409 (1991).

  11. 11

    Silver, M. L., Parker, K. C. & Wiley, D. C. Nature 350, 619–622 (1991).

  12. 12

    Rötzschke, O. et al. Nature 348, 252–254 (1990).

  13. 13

    Howard, J. C., Butcher, G. W., Galfre, G. & Milstein, C. Contemp. Topics Microbiol. Immun. 81, 54–60 (1978).

  14. 14

    Livingstone, A. M., Butcher, G. W. & Howard, J. C. Transplant. Proc. 15, 1557–1559 (1983).

  15. 15

    Livingstone, A. M. et al. J. exp. Med. 170, 777–795 (1989).

  16. 16

    Livingstone, A. M. et al. Immunogenetics 34, 157–163 (1991).

  17. 17

    Powis, S. J., Howard, J. C. & Butcher, G. W. Transplant. Proc. 22, 2517–2518 (1990).

  18. 18

    Powis, S. J., Howard, J. C. & Butcher, G. W. J. exp. Med. 173, 913–921 (1991).

  19. 19

    Deverson, E. V. et al. Nature 348, 738–741 (1990).

  20. 20

    Monaco, J. J., Cho, S. & Attaya, M. Science 250, 1723–1726 (1990).

  21. 21

    Trowsdale, J. et al. Nature 348, 741–744 (1990).

  22. 22

    Spies, T. et al. Nature 348, 744–747 (1990).

  23. 23

    Powis, S. J. et al. Nature 354, 528–531 (1991).

  24. 24

    Spies, T. & DeMars, R. Nature 351, 323–324 (1991).

  25. 25

    Kelly, A. et al. Nature 355, 641–644 (1992).

  26. 26

    Spies, T. et al. Nature 355, 644–646 (1992).

  27. 27

    Attaya, M. et al. Nature 355, 647–649 (1992).

  28. 28

    Townsend, A. R. M., Gotch, F. M. & Davey, J. Cell 42, 457–467 (1985).

  29. 29

    Garrett, T. P. J. et al. Nature 342, 692–696 (1989).

  30. 30

    Van Bleek, G. M. & Nathenson, S. G. Proc. natn. Acad. Sci. U.S.A. 88, 11032–11036 (1991).

  31. 31

    Falk, K., Rötzschke, O. & Rammensee, H-G. Nature 348, 248–251 (1990).

  32. 32

    Silva, A. et al. Immun. Rev. 76, 105–129 (1983).

  33. 33

    Rada, C. et al. Proc. natn. Acad. Sci. U.S.A. 87, 2167–2171 (1990).

  34. 34

    Bahram, S. et al. Proc. natn. Acad. Sci. U.S.A. 88, 10094–10098 (1991).

  35. 35

    Powis, S. H. et al. Proc. natn. Acad. Sci. U.S.A. 89, 1463–1467 (1992).

  36. 36

    Parham, P. Nature 348, 674–675 (1990).

  37. 37

    Robertson, M. Nature 353, 300–301 (1991).

  38. 38

    Lévy, F., Gabathuler, R., Larsson, R. & Kvist, S. Cell 67, 265–274 (1991).

  39. 39

    Anderson, K. et al. J. exp. Med. 174, 489–492 (1991).

  40. 40

    Choi, K., Chen, C., Kriegler, M. & Roninson, I. B. Cell 53, 519–529 (1988).

  41. 41

    Anderson, M. P. et al. Science 253, 202–205 (1991).

  42. 42

    Murphy, D. B. & Homer, R. J. in H-2 Antigens Genes, Molecules, Function (ed. David, C. S.) 359–369 (Plenum, New York, 1987).

  43. 43

    Pazmany, L. et al. J. exp. Med. 175, 361–369 (1992).

  44. 44

    Gunning, P. et al. Proc. natn. Acad. Sci. U.S.A. 84, 4831–4835 (1987).

  45. 45

    Butcher, G. W. J. Immunogenet. 14, 163–176 (1987).

  46. 46

    Chen, C-J. et al. Cell 47, 381–389 (1986).

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Powis, S., Deverson, E., Coadweil, W. et al. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature 357, 211–215 (1992). https://doi.org/10.1038/357211a0

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