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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

A Correction to this article was published on 18 June 1992

Abstract

NON-INSULIN-DEPENDENT diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown1,2. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify, the gene(s) predisposing to NIDDM. Here we report linkage between the glucokinase locus on chromosome 7p and diabetes in 16 French families with maturity-onset diabetes of the young, a form of NIDDM characterized by monogenic autosomal dominant transmission and early age of onset3. Statistical evidence of genetic heterogeneity was significant, with an estimated 45-95% of the 16 families showing linkage to glucokinase. Because glucokinase is a key enzyme of blood glucose homeostasis4, these results are evidence that a gene involved in glucose metabolism could be implicated in the pathogenesis of NIDDM.

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References

  1. Rahilly, S. O., Wainscoat, J. S. & Turner, R. C. Diabetologia 31, 407–414 (1988).

    Article  Google Scholar 

  2. Rich, S. S. Diabetes 39, 1315–1319 (1990).

    Article  CAS  PubMed  Google Scholar 

  3. Tattersall, R. B. & Fajans, S. S. Diabetes 24, 44–53 (1975).

    Article  CAS  PubMed  Google Scholar 

  4. Magnuson, M. A. Diabetes 39, 523–527 (1990).

    Article  CAS  PubMed  Google Scholar 

  5. Fajans, S. S. Diab. Metab. Rev. 5, 579–606 (1989).

    Article  CAS  Google Scholar 

  6. Fajans, S. S. Diabetes Care 13, 49–64 (1990).

    Article  CAS  PubMed  Google Scholar 

  7. Unger, R. H. Science 251, 1200–1205 (1991).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Chanson, Ph., Ferre, P. & Timsit, J. Méd. Sci. 7, 336–345 (1991).

    Google Scholar 

  9. Bell, G. I. et al. Proc. natn. Acad. Sci. U.S.A. 88, 1484–1488 (1991).

    Article  ADS  CAS  Google Scholar 

  10. O'Rahilly, S. et al. Diabetologia 31, 792–797 (1988).

    CAS  PubMed  Google Scholar 

  11. Multicentre Study (coord. Turner, R. C.) Diabetologia 24, 404–411 (1983).

  12. Lathrop, G. M., Lalouel, J. M., Julier, C. & Ott, J. Am. J. hum. Genet. 37, 482–498 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Rahilly, S. O. & Turner, R. C. Diab. Med 5, 224–229 (1988).

    Article  Google Scholar 

  14. Ott, J. in Human Genetic Diseases: A Practical Approach (ed. Davies, K. E.) 19–32 (IRL, Oxford, 1991).

    Google Scholar 

  15. De Fronzo, R. A. Diabetes 37, 667–687 (1988).

    Article  CAS  Google Scholar 

  16. Meglasson, M. A. & Matschinsky, F. M. Am. J. Physiol. 246, 1–13 (1984).

    Article  Google Scholar 

  17. Matschinsky, F. M. Diabetes 39, 647–652 (1990).

    Article  CAS  PubMed  Google Scholar 

  18. Magnuson, M. A. & Sheiton, K. D. J. biol. Chem. 27, 15936–15942 (1989).

    Google Scholar 

  19. Froguel, Ph., Velho, G. & Passa, Ph. Diabetologia 34, 685 (1991).

    Article  CAS  PubMed  Google Scholar 

  20. Economou, E. P., Bergen, A. W., Warren, A. C. & Antonarakis, S. E. Proc. natn. Acad. Sci. U.S.A. 87, 2951–2954 (1990).

    Article  ADS  CAS  Google Scholar 

  21. Tzall, S., Ellenbogen, A., Eng, F. & Hirschhorn, R. Am. J. hum. Genet. 44, 864–875 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Hazan, J., Dubay, C., Pankowiak, M. P., Becuwe, N. & Weissenbach, J. Genomics (in the press).

  23. Matsutani, A., Koranyi, L., Cox, N. & Permutt, A. Diabetes 39, 534–542 (1990).

    Article  Google Scholar 

  24. Froguel, Ph., Vionnet, N., Lesage, S., Velho, G. & Cohen, D. Nucleic. Acids Res. 19, 5799 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Froguel, Ph. et al. Nucleic. Acids Res. 19, 3754 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Matsutani, A., Janssen, R., Donis-Keller, H. & Permutt, M. A. Genomics 12, 319–325 (1992).

    Article  CAS  PubMed  Google Scholar 

  27. Mishra, S. M., Helms, C., Dorsey, D., Permutt, M. A. & Donis-Keller, H. Genomics 12, 326–334 (1992).

    Article  CAS  PubMed  Google Scholar 

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Froguel, P., Vaxillaire, M., Sun, F. et al. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356, 162–164 (1992). https://doi.org/10.1038/356162a0

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