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Genetic immunization is a simple method for eliciting an immune response

Abstract

To produce an immune reaction against a foreign protein usually requires purification of that protein, which is then injected into an animal. The isolation of enough pure protein is time-consuming and sometimes difficult. Here we report that such a response can also be elicited by introducing the gene encoding a protein directly into the skin of mice. This is achieved using a hand-held form of the biolistic system1–4 which can propel DNA-coated gold micro-projectiles directly into cells in the living animal3,5,6. Genetic immunization may be time- and labour-saving in producing antibodies and may offer a unique method for vaccination.

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Tang, Dc., DeVit, M. & Johnston, S. Genetic immunization is a simple method for eliciting an immune response. Nature 356, 152–154 (1992). https://doi.org/10.1038/356152a0

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