Letter | Published:

Electrically erodible polymer gel for controlled release of drugs

Nature volume 354, pages 291293 (28 November 1991) | Download Citation

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Abstract

NEW controlled drug-delivery systems are being explored to overcome the disadvantages of conventional dosage forms1. For example, stimulated drug-delivery has been used to overcome the tolerance problems that occur with a constant delivery rate, to mimic the physiological pattern of hormonal concentration and to supply drugs on demand1,2. Stimuli-sensitive polymers, which are potentially useful for pulsed drug delivery, experience changes in either their structure or their chemical properties in response to changes in environmental conditions2. Environmental stimuli include temperature3,4, pH5,6, light (ultraviolet7 or visible8), electric field9–12 or certain chemicals13. Volume changes of stimuli-sensitive gel networks are particularly responsive to external stimuli, but swelling is slow to occur14,15. As well as being useful in the controlled release of drugs, such systems also provide insight into intermolecular interactions16. Here we report on a novel polymeric system, which rapidly changes from a solid state to solution in response to small electric currents, by disintegration of the solid polymer complex into two water-soluble polymers. We show that the modulated release of insulin, and by extension other macromolecules, can be achieved with this polymeric system.

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References

  1. 1.

    Science 249, 1527–1533 (1990).

  2. 2.

    Kost, J. (ed.) Pulsed and Self-Regulated Drug Delivery (CRC, Boca Raton, 1990).

  3. 3.

    , & J. control. Release 4, 213–222 (1986).

  4. 4.

    , , & Makmmol. Chem. Rapid Commun. 8, 481–485 (1987).

  5. 5.

    , , & Nature 165, 514–516 (1950).

  6. 6.

    & Macromolecules 21, 3254–3259 (1988).

  7. 7.

    , , & J. Polym. Sci. Polym. Chem. 22, 881–884 (1984).

  8. 8.

    & Nature 346, 345–347 (1990).

  9. 9.

    , , & Science 218, 467–469 (1982).

  10. 10.

    & J. Polym. Sci. Polym. Lett. 19, 303–308 (1981).

  11. 11.

    & J. Membrane Sci. 19, 173–194 (1984).

  12. 12.

    , , , & Makromol. Chem., Macromol. Symp. 33, 265–277 (1990).

  13. 13.

    , & J. appl. Polym. Sci. 29, 211–217 (1984).

  14. 14.

    & J. chem. Phys. 81, 6379–6380 (1984).

  15. 15.

    , & Nature 349, 400–401 (1991).

  16. 16.

    & Adv. Polym. Sci. 45, 1–119 (1982).

  17. 17.

    , & Macromolecules 21, 2636–2641 (1988).

  18. 18.

    , & Polymer 29, 2285–2289 (1988).

  19. 19.

    in Controlled Release Polymeric Formulations (eds Paul, D. R. & Harris, F. W.) Ch. 3 (American Chemical Society, Washington, DC, 1976).

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Affiliations

  1. Center for Controlled Chemical Delivery, University of Utah, 421 Wakara Way, Salt Lake City, Utah 84108, USA

    • Ick Chan Kwon
    • , You Han Bae
    •  & Sung Wan Kim

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DOI

https://doi.org/10.1038/354291a0

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