Abstract
The crystallographically determined structure of simian virus 40 shows that the 72 pentamers of viral protein VP1, which form the outer shell, have identical conformations except for the C-terminal arms of their subunits. Five arms emerge from each pentamer and insert into neighbouring pentamers. This tying together of standard building blocks allows for the required variability in packing geometry without sacrificing specificity.
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References
Tooze, J. DNA Tumor Viruses (Cold Spring Harbor Laboratory, New York. 1980).
Rossman, M. G. & Johnson, J. E. A. Rev. Biochem. 58, 533–573 (1989).
Harrison, S. C. Harvey Lect. 85, 127–152 (1991).
Klug, A. J. molec. Biol. 11, 424–431 (1965).
Rayment, I., Baker, T. S., Caspar, D. L. D. & Murakami, W. T. Nature 295, 110–115 (1982).
Salunke, D., Caspar, D. L. D. & Garcea, R. L. Cell 46, 895–904 (1986).
Simpson, P. G., Dobrott, R. D. & Lipscomb, W. N. Acta crystallogr. 18, 169–179 (1965).
Argos, P. & Rossmann, M. Acta crystallogr. B32, 2975–2979 (1976).
Terwilliger, T. & Eisenberg, D. Acta crystallogr. A39, 813–817 (1983).
Rossmann, M. G. & Blow, D. M. Acta crystallogr. 16, 39–45 (1963).
Bricogne, G. Acta crystallogr. A32, 832–847 (1976).
Olson, A. J., Bricogne, G. & Harrison, S. C. J. molec. Biol. 171, 61–93 (1983).
Rossmann, M. G. et al. Nature 317, 145–153 (1985).
Moreland, R. B. & Garcea, R. L. Virology (in the press).
Moreland, R. B., Montross, L. & Garcea, R. L. J. Virol. 65, 1168–1176 (1991).
Brady, J. N., Winston, V. D. & Consigli, R. A. Virol. 23, 717–724 (1977).
Christiansen, G., Landers, T., Griffith, J. & Berg, P. J. Virol. 21, 1079–1084 (1977).
Walter, G. & Deppert, W. Cold Spring Harb. Symp. quant. Biol. 39, 255–257 (1974).
Blasquez, V., Beecher, S. & Bina, M. J. biol. Chem. 258, 8477–8484 (1983).
Baker, T. S., Drak, J. & Bina, M. Proc. natn. Acad. Sci. U.S.A. 85, 422–426 (1988).
Fried, H., Cahan, L. D. & Paulson, J. C. Virology 109, 188–192 (1981).
Freund, R., Calderone, A., Dawe, C. J. & Benjamin, T. L. J. Virol. 65, 335–341 (1991).
Dubensky, T. W., Freund, R., Dawe, C. J. & Benjamin, T. L. J. Virol. 65, 342–349 (1991).
Freund, R., Garcea, R. L., Sahli, R. & Benjamin, T. L. J. Virol. 65, 350–355 (1991).
Leavitt, A. D., Roberts, T. M. & Garcea, R. L. J. biol. Chem. 260, 12803–12809 (1985).
Salunke, D., Caspar, D. L. D. & Garcea, R. L. Biophys. J. 56, 887–900 (1989).
Garcea, R. L., Salunke, D. & Caspar, D. L. D. Nature 329, 86–87 (1987).
Kiselev, N. A. & Klug, A. J. molec. Biol. 40, 155–171 (1969).
Baker, T. S., Caspar, D. L. D. & Murakami, W. T. Nature 303, 446–448 (1983).
O'Farrell, P. Z. & Goodman, H. M. Cell 9, 289–298 (1976).
Garcea, R. L. & Benjamin, T. L. Proc. natn. Acad. Sci. U.S.A. 80, 3613–3617 (1983).
Ellis, R. J. & van der Vries, S. M. A. Rev. Biochem. 60, 321–348 (1991).
Harrison, S. C. Biophys. J. 32, 139–153 (1980).
Caspar, D. L. D. & Klug, A. Cold Spring Harb. Symp. quant. Biol. 27, 1–24 (1962).
Harrison, S. C. Trends Biochem. Sci. 9, 345–351 (1984).
Sorger, P. K., Stockley, P. G. & Harrison, S. C. J. molec. Biol. 191, 639–658 (1986).
Lattman, E. E. Science 208, 1048–1050 (1980).
Crawford, J. thesis, Harvard Univ. (1977).
Harrison, S. C. et al. Meth. Enzym. 114, 211–237 (1985).
Filman, D. J. et al. EMBO J. 8, 1567–1579 (1989).
Arnold, E. & Rossmann, M. G. J. molec. Biol. 211, 763–801 (1990).
Hogle, J. M., Kirchhausen, T. & Harrison, S. C. J. molec. Biol. 171, 95–100 (1983).
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Liddington, R., Yan, Y., Moulai, J. et al. Structure of simian virus 40 at 3.8-Å resolution. Nature 354, 278–284 (1991). https://doi.org/10.1038/354278a0
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DOI: https://doi.org/10.1038/354278a0
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