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CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1

Nature volume 354, pages 233235 (21 November 1991) | Download Citation

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Abstract

THE protein CD43 (also known as sialophorin, leukosialin, large sialoglycoprotein or gp115) is expressed on the surface of T lymphocytes, monocytes, neutrophils, platelets and some B lymphocytes1–6. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome7, suggesting that CD43 might have a role in T-cell activation. We have shown that expression of human CD43 in an HLA-DR-specific murine T-cell hybridoma enhances the antigen-specific response to stimulation by the human lympho-blastoid cell line Daudi, and that Daudi cells bind specifically to purified immobilized CD43 (ref. 8). These data indicate that the specific interaction of CD43 with a ligand on the surface of Daudi cells might contribute to T-cell activation. Here we report evidence that intercellular adhesion molecule-1 (ICAM-1, or CD54), is a ligand for CD43.

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Affiliations

  1. Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA

    • Yvonne Rosenstein
    • , John K. Park
    • , William C. Hahn
    • , Barbara E. Bierer
    •  & Steven J. Burakoff
  2. The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA

    • Fred S. Rosen
  3. Hematology-Oncology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

    • Barbara E. Bierer
  4. The Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA

    • Yvonne Rosenstein
  5. The Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA

    • Fred S. Rosen
    •  & Steven J. Burakoff
  6. The Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA

    • Barbara E. Bierer

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https://doi.org/10.1038/354233a0

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