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Molecular cloning and characterization of the rat NMDA receptor

Nature volume 354, pages 3137 (07 November 1991) | Download Citation

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Abstract

A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

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Affiliations

  1. Institute for Immunology, Kyoto University Faculty of Medicine, Kyoto 606, Japan

    • Koki Moriyoshi
    • , Masayuki Masu
    • , Takahiro Ishii
    •  & Shigetada Nakanishi
  2. Department of Morphological Brain Science, Kyoto University Faculty of Medicine, Kyoto 606, Japan

    • Ryuichi Shigemoto
    •  & Noboru Mizuno

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https://doi.org/10.1038/354031a0

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