Abstract
The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a represser of normal gene activity during heat stress.
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Westwood, J., Clos, J. & Wu, C. Stress-induced oligomerization and chromosomal relocalization of heat-shock factor. Nature 353, 822–827 (1991). https://doi.org/10.1038/353822a0
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DOI: https://doi.org/10.1038/353822a0
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