Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

Nature volume 353, pages 262–265 (1991)Cite this article

Abstract

HUMAN type 1 (insulin-dependent) diabetes is a common autoimmune disease of the insulin-producing β cells of the pancreas which is caused by both genetic and environmental factors1,2. Several features of the genetics and immunopathology of diabetes in nonobese diabetic (NOD) mice are shared with the human disease1,3,4. Of the three diabetes-susceptibility genes, Idd-1 (refs 5–7), -3 and -4 (ref. 4) that have been mapped in mice to date, only in the case of Idd-1 is there any evidence for the identity of the gene product: allelic variation within the murine immune response /-A/3 gene and its human homologue HLA-DQB1 correlates with susceptibility, implying that I–Aβ is a component of Idd-1 (refs 5–11). We report here the mapping of Idd-5 to the proximal region of mouse chromosome 1. This region contains at least two candidate susceptibility genes, the interleukin-1 receptor gene (Il-lrl; ref. 12) and Lsh/Ity/Bcg (refs 13-19), which encodes resistance to bacterial and parasitic infections and affects the function of macrophages.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Castano, L. & Eisenbarth, G. S. A. Rev. Immun. 8, 647–679 (1990).

    Article  CAS  Google Scholar 

  2. Risch, N. Am. J. hum. Genet. 40, 1–14 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Makino, S. et al. Expl Anim. 29, 1–13 (1980).

    Article  CAS  Google Scholar 

  4. Todd, J. A. et al. Nature 351, 542–547 (1991).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Hattori, M. et al. Science 231, 733–735 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Prochazka, M., Leiter, E. H., Serreze, D. V. & Coleman, D. L. Science 237, 286–289 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Wicker, L. S. et al. J. exp. Med. 165, 1639–1654 (1987).

    Article  CAS  PubMed  Google Scholar 

  8. Todd, J. A., Bell, J. I. & McDevitt, H. O. Nature 329, 599–604 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Miyazaki, T. et al. Nature 345, 722–724 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Slattery, R. M. et al. Nature 345, 724–726 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Lund, T. et al. Nature 345, 727–729 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Copeland, N. G. et al. Genomics 9, 44–50 (1991).

    Article  CAS  PubMed  Google Scholar 

  13. Blackwell, J. M. et al. Immun. Lett. (in the press).

  14. Schurr, E. et al. Immun. Today 12, 42–45 (1991).

    Article  Google Scholar 

  15. Skamene, E. et al. Nature 297, 506–509 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Malo, D. et al. Genomics 10, 356–364 (1991).

    Article  CAS  PubMed  Google Scholar 

  17. Mock, B. et al. Genomics 7, 57–64 (1990).

    Article  CAS  PubMed  Google Scholar 

  18. Hillyard, A. L., Doolittle, D. P., Davisson, M. T. & Roderick, T. H. Locus Map of the Mouse with Comparative Points of Human on Mouse (Jackson Laboratory, Barbor, Maine, 1991).

    Google Scholar 

  19. Hutchings, P. et al. Nature 348, 639–642 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Harada, M. & Makino, S. Diabetologia 27, 604–606 (1984).

    Article  CAS  PubMed  Google Scholar 

  21. Yasunami, R. & Bach, J.-F. Eur. J. Immun. 18, 481–484 (1988).

    Article  CAS  Google Scholar 

  22. Wicker, L. S., DeLarato, N. H., Pressey, A. & Peterson, L. B. in Proc. P & S Biomed. Sci. Symp.; Molecular Mechanisms of Immunological Self-recognition (eds Vogel, H. J. & Alt, S. W.) (Academic, New York, in the press).

  23. Wicker, L. S., DeLareto, N. H., Pressey, A. & Peterson, L. B. in Frontiers in Diabetes Research II: Lessons from Animal Diabetes III (ed. Shafrir, E.) 67–72 (Smith-Gordon, London, 1991).

    Google Scholar 

  24. Jacob, C. O., Aiso, S., Michie, S. & McDevitt, H. O. Proc. natn. Acad. Sci. U.S.A. 87, 968–972 (1990).

    Article  ADS  CAS  Google Scholar 

  25. Mandrup-Poulsen, T. et al. Curr. Topics Microbial. Immun. 164, 169–193 (1990).

    CAS  Google Scholar 

  26. Sims, J. E. et al. Science 241, 585–589 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Love, J. M., Knight, A. M., McAleer, M. A. & Todd, J. A. Nucleic Acids Res. 18, 4123–4130 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Cornall, R. J., Aitman, T. J., Hearne, C. M. & Todd, J. A. Genomics 10, 874–881 (1991).

    Article  CAS  PubMed  Google Scholar 

  29. Hearne, C. M. et al. Mamm. Genome 1, 273–282 (1991).

    Article  CAS  PubMed  Google Scholar 

  30. Hogarth, P. M. et al. J. Immun. 146, 369–377 (1991).

    CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Alison Pressey, Nicole H. DeLarato and Linda S. Wicker: Autoimmune Diseases Research, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065, USA

  2. Laurence B. Peterson: Department of Cellular and Molecular Pharmacology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065, USA

Authors and Affiliations

  1. Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, 0X3 9DU, UK

    Richard J. Cornall, Jan-Bas Prins, John A. Todd, Alison Pressey, Nicole H. DeLarato, Linda S. Wicker & Laurence B. Peterson

Authors
  1. Richard J. Cornall
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jan-Bas Prins
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. John A. Todd
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alison Pressey
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nicole H. DeLarato
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Linda S. Wicker
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Laurence B. Peterson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cornall, R., Prins, JB., Todd, J. et al. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1. Nature 353, 262–265 (1991). https://doi.org/10.1038/353262a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/353262a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing