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The B-cell antigen receptor of the five immunoglobulin classes

Naturevolume 352pages777781 (1991) | Download Citation

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Abstract

Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the α and β associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, α common a chain associ-ates with all five immunoglobulin classes. We pro-pose that B-cell antigen receptors consist of a common α/β heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated α chain and in their dependence on α/β for surface transport.

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Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    • Ashok R. Venkitaraman
    • , Gareth T. Williams
    • , Piona Dariavach
    •  & Michael S. Neuberger
  2. Laboratoire d'lmmunogénétique Moléculaire, Université de Montpellier II, France

    • Piona Dariavach

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https://doi.org/10.1038/352777a0

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