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Breakdown of self-tolerance in anergic B lymphocytes

Nature volume 352, pages 532536 (08 August 1991) | Download Citation

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Abstract

PRODUCTION of autoantibodies, which characterizes most autoimmune diseases, is normally avoided by active elimination1–7 or functional inactivation (anergy) 8–15 of B and T lymphocytes bearing receptors for self antigens. The mechanisms leading to the escape of self-reactive clones from these normal tolerance mechanisms in autoimmune diseases nevertheless remain obscure. Here, we demonstrate that clonal anergy in B lymphocytes is a reversible process, and that silenced self-reactive B cells can be reactivated under particular conditions to give rise to vigorous antibody responses. Reactivation of anergic lymphocytes may explain many examples of transient autoimmune reactions in normal individuals, and may under pathological conditions be important in the development of chronic autoimmune disease.

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Author information

Author notes

    • Christopher C. Goodnow

    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Beckman Center, Stanford University, California 94305, USA

Affiliations

  1. Centenary Institute for Cancer Medicine and Cell Biology, University of Sydney, New South Wales 2006, Australia

    • Christopher C. Goodnow
    • , Robert Brink
    •  & Elizabeth Adams

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About this article

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DOI

https://doi.org/10.1038/352532a0

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