Letter | Published:

Prevention of HIV-2 and SIVsm infection by passive immunization in cynomolgus monkeys

Naturevolume 352pages436438 (1991) | Download Citation

Subjects

Abstract

INFECTION of macaques with simian immunodeficiency virus (SIV)1,2 and human immunodeficiency virus type 2 (HIV-2) 3,4 are useful models for studies of immunotherapy and vaccination against HIV as well as for testing of antiviral drugs. Vaccine research showing protective immunity in immunized monkeys4–10 has indicated that it will be possible to develop a vaccine for prevention of human HIV infection, although many hurdles remain. The design of an HIV vaccine would be helped if the basis of the protective immunity could be elucidated. Passive immune prophylaxis offers a means to determine the relative role of antibodies in protection against infection. We have studied whether a transfer of antibodies can prevent HIV-2 and SIVsm (SIV of sooty mangabey origin) infection in cynomolgus monkeys. Sera with high antibody titres were collected, heat-treated and injected into naive animals 6 h before challenge with 10–100 monkey-infectious doses of live homologous virus. All control animals treated with normal monkey serum (n = 6) or no serum (n = 39) became infected by the challenge virus, whereas five out of seven animals pretreated with antibody-containing serum at a dose of 9 ml kg−1 resisted infection. Thus passively transferred antibodies can protect against a low-dose lentivirus challenge in a nonhuman primate.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Desrosiers, R. C. & Ringler, D. J. Intervirology 30, 301–312 (1989).

  2. 2

    Putkonen, P. et al. J. AIDS 2, 359–365 (1989).

  3. 3

    Putkonen, P. et al. J. AIDS 2, 366–373 (1989).

  4. 4

    Putkonen, P. et al. AIDS Res. hum. Retrovir. 7, 271–277 (1991).

  5. 5

    Desrosiers, R. C. et al. Proc. natn Acad Sci. U.S.A. 86, 6353–6357.

  6. 6

    Murphey-Corb, M. et al. Science 246, 1293–1297 (1989).

  7. 7

    Berman, P. W. et al. Nature 345, 622–625 (1990).

  8. 8

    Putkonen, P. et al. AIDS 4, 783–789 (1990).

  9. 9

    Carlson, J. R. et al. AIDS. Res. hum. Retrovir. 6, 1239–1246 (1990).

  10. 10

    Stott, E. J. et al. Lancet 336, 1538–1541 (1990).

  11. 11

    Prince, A. M. et al. Proc. natn. Acad. Sci. U.S.A. 85, 6944–6948 (1988).

  12. 12

    Hunsmann, G., Moennig, V. & Schäfer, W. Virology 66, 327–329 (1975).

  13. 13

    De Noronha, F., Schäfer, W., Essex, M. & Bolognesi, D. P. Virology 85, 617–621 (1978).

  14. 14

    Kataoka, R. et al. Blood 76, 1657–1661 (1990).

  15. 15

    Biberfeld, G., Thorstensson, R., Bergström, M. & Naucler, A. AIDS 2, 195–199 (1988).

  16. 16

    Norrby, E., Putkonen, P., Böttiger, B., Utter, G. & Biberfeld, G. AIDS Res. hum. Retrovir. 7, 279–285 (1991).

  17. 17

    Björling, E. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).

  18. 18

    Thorstensson, R., Walther, L., Putkonen, P., Albert, J. & Biberfeld, G. J. AIDS 4, 374–379 (1991).

  19. 19

    Albert, J. et al. AIDS 4, 291–295 (1990).

  20. 20

    Albert, J. & Fenyö, E. M. J. clin. Microbiol. 28, 1560–1564 (1990).

Download references

Author information

Affiliations

  1. Department of Immunology, National Bacteriological Laboratory, S-10521, Stockholm, Sweden

    • Per Putkonen
    • , Rigmor Thorstensson
    • , Lili Ghavamzadeh
    • , Kerstin Hild
    •  & Gunnel Biberfeld
  2. Department of Virology, National Bacteriological Laboratory, S-10521, Stockholm, Sweden

    • Jan Albert
  3. Department of Virology, Karolinska Institute, S-10521, Stockholm, Sweden

    • Erling Norrby

Authors

  1. Search for Per Putkonen in:

  2. Search for Rigmor Thorstensson in:

  3. Search for Lili Ghavamzadeh in:

  4. Search for Jan Albert in:

  5. Search for Kerstin Hild in:

  6. Search for Gunnel Biberfeld in:

  7. Search for Erling Norrby in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/352436a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.