Multiple modes of engrailed regulation in the progression towards cell fate determination

Nature volume 352, pages404–410(1991)Cite this article

Abstract

The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed- independent mode of maintenance.

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Affiliations

  1. Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, California, 94143-0448, USA

    Jill Heemskerk & Patrick H. O'Farrell

  2. The Rockefeller University, 1230 York Avenue, New York, New York, 10021-6399, USA

    Stephen DiNardo

  3. Department of Molecular and Cell Biology, DC Berkeley, Berkeley, California, 94720, USA

    Richard Kostriken

Authors
  1. Jill Heemskerk
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  2. Stephen DiNardo
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  3. Richard Kostriken
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  4. Patrick H. O'Farrell
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Heemskerk, J., DiNardo, S., Kostriken, R. et al. Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature 352, 404–410 (1991). https://doi.org/10.1038/352404a0

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