Multiple modes of engrailed regulation in the progression towards cell fate determination

Abstract

The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed- independent mode of maintenance.

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References

  1. 1

    Slack, J. M. W. From Egg to Embryo: Determinative Events in Early Development. (Cambridge University Press, Cambridge, 1983).

    Google Scholar 

  2. 2

    Garcia-Bellido, A. CIBA Fdn Symp. 29, 161–182 (1975).

    Google Scholar 

  3. 3

    Lawrence, P. A. & Morata, G. Devl Biol. 50, 321–337 (1976).

    CAS  Article  Google Scholar 

  4. 4

    Kornberg, T., Siden, I., O'Farrell, P. & Simon, M. Cell 40, 45–53 (1985).

    CAS  Article  Google Scholar 

  5. 5

    Garcia-Bellido, A., Ripoll, P. & Morata, G. Nature 245, 251–253 (1973).

    CAS  Article  Google Scholar 

  6. 6

    Garcia-Bellido, A., Ripoll, P. & Morata, G. Devl Biol. 48, 132–147 (1976).

    CAS  Article  Google Scholar 

  7. 7

    Kornberg, T. Proc. natn. Acad. Sci. U.S.A. 78, 1095–1099 (1981).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Baker, N. E. EMBO J. 6, 1765–1773 (1987).

    CAS  Article  Google Scholar 

  9. 9

    van den Heuvel, M., Nusse, R., Johnston, P. & Lawrence, P. A. Cell 59, 739–749 (1989).

    CAS  Article  Google Scholar 

  10. 10

    Rijsewijk, F. et al. Cell 50, 649–657 (1987).

    CAS  Article  Google Scholar 

  11. 11

    DiNardo S., Sher, E., Heemskerk-Jongens, J., Kassis, J. A. & O'Farrell, P. H. Nature 332, 45–53 (1988).

    Article  Google Scholar 

  12. 12

    Martinez-Arias, A., Baker, N. & Ingham, P. W. Development 103, 157–170 (1988).

    CAS  Google Scholar 

  13. 13

    Baker, N. E. Devl Biol. 125, 96–108 (1988).

    CAS  Article  Google Scholar 

  14. 14

    DiNardo, S., Kuner, J. M., Theis, J. & O'Farrell, P. H. Cell 43, 59–69 (1985).

    CAS  Article  Google Scholar 

  15. 15

    Jaynes, J. B. & O'Farrell, P. H. EMBO J. 10, 1427–1433 (1991).

    CAS  Article  Google Scholar 

  16. 16

    Poole, S. J. & Kornberg, T. B. Development suppl. 104, 85–93 (1988).

    Google Scholar 

  17. 17

    Kassis, J. A., Genes Dev. 4, 433–443 (1990).

    CAS  Article  Google Scholar 

  18. 18

    DiNardo, S. & O'Farrell, P. H. Genes Dev. 1, 1212–1225 (1987).

    CAS  Article  Google Scholar 

  19. 19

    Howard, K. & Ingham, P. Cell 44, 949–957 (1986).

    CAS  Article  Google Scholar 

  20. 20

    Cline, T. Genetics 107, 231–277 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. 21

    Kuziora, M. A. & McGinnis, W. Cell 55, 477–485 (1988).

    CAS  Article  Google Scholar 

  22. 22

    Thayer, M. J. et al. Cell 58, 241–248 (1989).

    CAS  Article  Google Scholar 

  23. 23

    Wedeen, C., Harding, K. & Levine, M. Cell 44, 739–748 (1986).

    CAS  Article  Google Scholar 

  24. 24

    Struhl, G. & Akam, M. EMBO J. 4, 3259–3264 (1985).

    CAS  Article  Google Scholar 

  25. 25

    Mazo, A. M., Huang, D.-K., Mozer, B. A. & Dawid, I. B. Proc. natn. Acad. Sci. U.S.A. 87, 2112–2116 (1990).

    ADS  CAS  Article  Google Scholar 

  26. 26

    Busturia, A. & Morata, G. Development 104, 713–720 (1988).

    CAS  PubMed  Google Scholar 

  27. 27

    Dura, J. M. & Ingham, P. Development 103, 733–741 (1988).

    CAS  PubMed  Google Scholar 

  28. 28

    Smouse, D., Goodman, C., Mahowald, A. & Perrimon, N. Genes Dev. 2, 830–842 (1988).

    CAS  Article  Google Scholar 

  29. 29

    Spradling, A. C. & Rubin, G. M. Science 218, 341–347 (1982).

    ADS  CAS  Article  Google Scholar 

  30. 30

    Tautz, D. & Pfeifle, C. Chromosoma 98, 81–85 (1989).

    CAS  Article  Google Scholar 

  31. 31

    Baker, N. E. Development 103, 289–298 (1988).

    CAS  PubMed  Google Scholar 

  32. 32

    Poole, S. J., Kauvar, L. M., Drees, B. & Kornberg, T. Cell 40, 37–43 (1985).

    CAS  Article  Google Scholar 

  33. 33

    Pirotta, V. in Vectors, A Survey of Molecular Cloning Vectors and their Uses, (eds Rodriguez, R. L. & Denhardt, D. T.) 437–456 (Butterworths. Boston, 1988).

    Google Scholar 

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Heemskerk, J., DiNardo, S., Kostriken, R. et al. Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature 352, 404–410 (1991). https://doi.org/10.1038/352404a0

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